Akt Inhibitor XIA cell-permeable copper complex that inhibits Akt kinase activity

Akt Inhibitor XI (CAS 902779-59-3)

Akt Inhibitor XI | CAS 902779-59-3 is rated 5.0 out of 5 by 1.
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Synonym: FPA 124; 3-Formylchromone thiosemicarbazone; Cu(II)Cl2 Complex
Application: A cell-permeable copper complex that inhibits Akt kinase activity
CAS Number: 902779-59-3
Molecular Weight: 381.7
Molecular Formula: C11H9Cl2CuN3O2S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Akt Inhibitor XI is a cell-permeable copper complex that interacts with both the pH and the kinase domains of Akt and potently inhibits its kinase activity. Akt Inhibitor XI inhibits tumor growth both in cultured cells in vitro.


References

1. Barve, V. et al. 2006. J. Med. Chem. 49(13): 3800-3808. PMID: 16789737

2. Rybchyn, M. S. et al. 2011. J. Biol. Chem. 268(27): 23771-2377-. PMID: 21566129

Physical State :
Solid
Solubility :
Soluble in water (5 mg/ml), DMSO (2 mg/ml), and ethanol (10 mM).
Storage :
Store at 4° C
IC50 :
Akt kinase activity: IC50 = 100 nM; tumor growth: IC50 = 10-34 µM (cultured cells)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
SMILES :
C1=CC=CC2=C1OC=C(C2=O)C=[N]3NC(=[S][Cu]3(Cl)Cl)N

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Akt Inhibitor XI  Product Citations

See how others have used Akt Inhibitor XI. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 27297104  Okoro, EU. et al. 2016. Biochemical and biophysical research communications.

PMID: # 27165344  Thomas, L. et al. 2016. Kidney & blood pressure research. 41: 298-310.

PMID: # 24692543  Zhou, L. et al. 2014. J. Biol. Chem. 289: 12989-99.

Citations 1 to 3 of 3 total

Does Akt inhibitor XI (cas: 902779-59-3) inhibit Akt1, Akt2 and Akt3 or just one/two of them? Thank you

Asked by: Ariel5
Thank you for your question. Unfortunately, we could not find a literature reference specifying this information. Please refer to the references below which may be helpful. These will be added to our website in the future. 1. Barve, V. et al. 2006. J. Med. Chem. 49(13): 3800-3808. PMID: 16789737 2. Rybchyn, M. S. et al. 2011. J. Biol. Chem. 268(27): 23771-2377-. PMID: 21566129
Answered by: Technical Support
Date published: 2018-11-30
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Rated 5 out of 5 by from Various publications cite Akt inhibitor XI Various publications cite Akt inhibitor XI as a cell-permeable copper complex used for the inhibition of Akt kinase activity. -SCBT Publication Review
Date published: 2015-04-05
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