Akt Inhibitor IVAn Inhibitor of Akt protein kinase

Akt Inhibitor IV (CAS 681281-88-9)

Akt Inhibitor IV | CAS 681281-88-9 is rated 5.0 out of 5 by 1.
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Synonym: 5-(2-Benzothiazolyl)-3-ethyl-2-[2-(methylphenylamino)ethenyl]-1-phenyl-1H-benzimidazolium iodide
Application: An Inhibitor of Akt protein kinase
CAS Number: 681281-88-9
Purity: ≥98%
Molecular Weight: 614.54
Molecular Formula: C31H27N4S•I
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Akt Inhibitor IV Inhibits Akt protein kinase. Reports indicate that Akt inhibitor IV targets the ATP-binding site of a kinase upstream of AKT and downstream of PI3K. Akt inhibitor IV was observed to increase the sensitivity of glioma cells to radiaton.


References

1. Wang, G., et al. 2006. Proc. Natl. Acad. Sci. U.S.A. 103: 4640-4645. PMID: 16537421
2. Huang, S.C., et al. 2010. Int J Parasitol. PMID: 20654619
3. Chautard, E., et al. 2010. Neuro-oncology. 12: 434-443. PMID: 20406894
4. Choi, J.I., et al. 2010. Pain. 149: 243-253. PMID: 20202754
5. Jeon, S.J. et al. 2011. J. Biomed. Sci. 18 : 17. PMID: 21314987

Physical State :
Solid
Solubility :
Soluble in DMSO (≥10 mg/ml).
Storage :
Store at 4° C
IC50 :
Akt-mediated FOXO1a nuclear export: IC50 = 625 nM; cell proliferation: IC50 = <1.25 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
5719375
MDL Number :
MFCD00570739
SMILES :
CC[N+]1=C(N(C2=C1C=C(C=C2)C3=NC4=CC=CC=C4S3)C5=CC=CC=C5)C=CN(C)C6=CC=CC=C6.[I-]

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Certificate of Analysis

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Akt Inhibitor IV  Product Citations

See how others have used Akt Inhibitor IV. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 24 total

PMID: # 29887521  Zhi, H.|Gong, FH.|Cheng, WL.|Zhu, K.|Chen, L.|Yao, Y.|Ye, X.|Zhu, XY.|Li, H.| et al. 2018. J Am Heart Assoc. 7:

PMID: # 28350788  Naito, S.|Makhov, P.|Astsaturov, I.|Golovine, K.|Tulin, A.|Kutikov, A.|Uzzo, RG.|Kolenko, VM.| et al. 2017. Br. J. Cancer. 116: 1203-1207.

PMID: # 28260004  Jia, Y.|Wang, HD.|Wang, Q.|Ding, H.|Wu, HM.|Pan, H.| et al. 2017. Oncol. Rep. 37: 2252-2260.

PMID: # 27756325  Cepeda, MA. et al. 2016. Mol. Cancer. 15: 65.

PMID: # 25823028  Xi, G. et al. 2016. Oncogene. 35: 241-50.

PMID: # 26889770  Li, J. et al. 2016. Canadian journal of physiology and pharmacology. 94: 517-25.

PMID: # 26165142  Sun, P. et al. 2015. Journal of hepatology. 63: 1198-211.

PMID: # 25445688  Jin, JO. et al. 2015. International journal of biological macromolecules. 73: 65-71.

PMID: # 25661333  Liu, Z. et al. 2015. Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie. 69: 24-8.

PMID: # 25200832  Li, R. et al. 2015. Journal of neuro-oncology. 121: 83-9.

Citations 1 to 10 of 24 total

Dear sir/madam, I am working at Maastricht University. Is it possible to buy a product (CAS: 681281-88-9) and pay in Netherlands then you ship it to Zagazig University in Egypt? How much would this cost? Thanks in advance, Regards, Mahmoud

Asked by: Elbatrik
Thank you for your question. Please contact your local distributor or technical service for further assistance.
Answered by: Tech Service
Date published: 2019-02-12

What is the meaning of &quot;a kinase upstream of AKT and downstream of PI3K&quot; ?

Asked by: two2igm05
Thank you for your question. Akt Inhibitor IV, sc-203809, inhibits Akt phosphorylation during the AKT/PKB signaling pathway after PI 3-K, but before Akt, activates the ATP binding site on the plasma membrane.
Answered by: Chemical Support 4
Date published: 2017-03-03
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Rated 5 out of 5 by from Jeon Jeon, SJ. et al. (PubMed 21314987) used product sc-203809 (Akt Inhibitor IV) to verify the role of the Akt pathway in the regulation of FMRP induction in HeLa cells. Akt Inhibitor decreased expression of Akt in a concentration dependent manner. They additionally used product sc-202048 (Akt Inhibitor VIII) and noted similar results. -SCBT Publication Review
Date published: 2015-01-12
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