AIDACAS: 168560-79-0
MF: C11H11NO4
MW: 221.21
A potent and selective group I mGluR agonist.

AIDA (CAS 168560-79-0)

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Synonym: 1-aminoindan-1,5-dicarboxylic acid
Application: A potent and selective group I mGluR agonist
CAS Number: 168560-79-0
Purity: ≥96%
Molecular Weight: 221.21
Molecular Formula: C11H11NO4
* Refer to Certificate of Analysis for lot specific data (including water content).
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AIDA, or 1-aminoindan-1,5-dicarboxylic acid, is a selective antagonist of mGluR (the group I metabotropic glutamate receptor). AIDA is described to competitively antagonize the stimulatory response of glutamate in cells transfected with mGluR-1a. AIDA has been used as a tool for elucidating the role of mGluR-1 receptors in various processes, where antagonism by AIDA has identified participation of the mGluR-1in hippocampus-dependent learning tasks.


References

1. Nielsen, K.S., et al. 1997. Eur. J. Pharmacol. 326: 105-108. PMID: 9196260
2. Moroni, F., et al. 1997. J. Pharmacol. Exp. Ther. 281: 721-729. PMID: 9152378
3. Mukhin, A.G., et al. 1997. Neuroreport. 8: 2561-2566. PMID: 9261827
4. Pellegrini-Giampietro, D.E., et al. 1999. Eur. J. Neurosci. 11: 3637-3647. PMID: 10564371
5. Schoepp, D.D., et al. 1999. Neuropharmacology. 38: 1431-1476. PMID: 10530808
6. Salt, T.E., et al. 1999. Neuropharmacology. 38: 1505-1510. PMID: 10530812
7. Camodeca, N., et al. 1999. Neuropharmacology. 38: 1597-1606. PMID: 10530821

Physical State :
Solid
Solubility :
Soluble in DMSO (2 mg/mL), and water.
Storage :
Store at 4° C
Melting Point :
299.12° C (Predicted)
Boiling Point :
470.36° C at 760 mmHg (Predicted)
Density :
1.48 g/cm3 (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
IC50 :
Plasmodium falciparum: EC5050 = 833 nM (Plasmodium falciparum); mGluR-1a: IC50 = 7 µM (human)
Ki Data :
mGluR-1a: Ki= 214 µM (human); mGluR-4: Ki= >1 mM (human); mGluR-2: Ki= >1 mM (human); mGluR-5: Ki= >1 mM (human)
pK Values :
pKa: 1.63 (Predicted), pKb: 10.24 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
NK8330300
PubChem CID :
2071
MDL Number :
MFCD00672638
SMILES :
C1CC(C2=C1C=C(C=C2)C(=O)O)(C(=O)O)N

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Certificate of Analysis

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AIDA  Product Citations

See how others have used AIDA. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 26539627  Sato, K. et al. 2016. Biosci. Biotechnol. Biochem. 80: 712-8.

Citations 1 to 1 of 1 total
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