AICARCAS: 2627-69-2
MF: C9H14N4O5
MW: 258.23
An inhibitor of the transcription of PPARα, the coactivation of PPARα.

AICAR (CAS 2627-69-2)

AICAR | CAS 2627-69-2 is rated 5.0 out of 5 by 1.
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Synonym: Acadesine; 5-Aminoimidazole-4-carboxamide; 1-β-D-ribofuranoside
Application: An inhibitor of the transcription of PPARα, the coactivation of PPARα
CAS Number: 2627-69-2
Purity: ≥98%
Molecular Weight: 258.23
Molecular Formula: C9H14N4O5
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

AICAR (AICA-Riboside) strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK (AMP-activated protein kinase), and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.


References

1. Corton, J.M., et al. 1995. Eur. J. Biochem. 229: 558-565. PMID: 7744080
2. Lochhead, P.A., et al. 2000. Diabetes. 49: 896-903. PMID: 10866040
3. Habinowski, S.A., et al. 2001. Biochem. Biophys. Res. Commun. 286: 852-856. PMID: 11527376
4. Vergis, J.M., et al. 2001. J. Biol. Chem. 276: 7727-7733. PMID: 11096114
5. Bronner, M., et al. 2004. Biochem. J. 384: 295-305. PMID: 15312046

Physical State :
Solid
Solubility :
Soluble in water (9 mg/ml), and DMSO (75 mM).
Storage :
Store at -20° C
Melting Point :
214-215° C
Boiling Point :
~726.3° C at 760 mmHg (Predicted)
Density :
~2.1 g/cm3 (Predicted)
Refractive Index :
n20D 1.82
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
16078949
MDL Number :
MFCD00869751
EC Number :
220-097-5
SMILES :
NC(=O)C1=C(N)N(C=N1)[C@@H]1O[C@H](CO)C(O)[C@@H]1O

Download SDS (MSDS)

Certificate of Analysis

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AICAR  Product Citations

See how others have used AICAR. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 33 total

PMID: # 30774777  Rae, C. et al. 2019. Oncotarget. 10: 749-759.

PMID: # 30161162  Tsogbadrakh, B.|Ju, KD.|Lee, J.|Han, M.|Koh, J.|Yu, Y.|Lee, H.|Yu, KS.|Oh, YK.|Kim, HJ.|Ahn, C.|Oh, KH.| et al. 2018. PLoS ONE. 13: e0201692.

PMID: # 29946343  Samuels, JS. et al. 2018. Nutr Metab (Lond). 15: 42.

PMID: # 29785900  Li, X. et al. 2018. J. Dairy Res. 85: 157-162.

PMID: # 27431894  Choi, JH.|Kim, SW.|Yu, R.|Yun, JW.| et al. 2017. Eur J Nutr. 56: 2329-2341.

PMID: # 28213467  Xue, J. et al. 2017. Am. J. Physiol. Lung Cell Mol. Physiol. 312: L568-L578.

PMID: # 28649994  Dogliotti, G. et al. 2017. Nat Commun. 8: 15747.

PMID: # 29089450  Sandí, MJ. et al. 2017. Sci Signal. 10:

PMID: # 28988114  Tao, X. et al. 2017. Biochem. Biophys. Res. Commun. 494: 615-620.

PMID: # 26919657  Fodor, T. et al. 2016. PLoS ONE. 11: e0150232.

Citations 1 to 10 of 33 total

请问AICAR在水中和DMSO中溶解度分别多少

Asked by: huaxianzi1985
感谢您的提问。AICAR:sc-200659在水中的溶解度为9 mg/ml,在DMSO中的溶解度为75 mM。更多问题,欢迎通过:电话(+86) 021-60936350、邮箱asia@scbio.cn、或选择网页上Live Chat中的“中文支持”,联系我们的技术支持部门。 Thank you for your question. AICAR: sc-200659 is soluble in water (9 mg/ml) and DMSO (75 mM). If you have any further questions, please contact our Asian Technical Service team at (+86) 021-60936350 or asia@scbio.cn or by live chat on our website.
Answered by: Technical Support 14
Date published: 2019-03-20

What is the exact purity of this compound?

Asked by: two2igm05
Thank you for your question. The exact purity varies lot to lot, so please request a current CoA to see the purity of the current lot. Purity is normally determined by HPLC or TLC. Please contact Technical Service if you have further questions concerning this product.
Answered by: Tech Service 9
Date published: 2016-12-20
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Rated 5 out of 5 by from Got good results in our experiments Got good results in our experiments, happy with it.
Date published: 2015-06-17
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