AH-6809A prostaglandin E2 receptor antagonist

AH-6809 (CAS 33458-93-4)

AH-6809 | CAS 33458-93-4 is rated 5.0 out of 5 by 1.
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Synonym: 6-Isopropoxy-9-oxoxanthene-2-carboxylic acid
Application: A prostaglandin E2 receptor antagonist
CAS Number: 33458-93-4
Purity: ≥98%
Molecular Weight: 298.29
Molecular Formula: C17H14O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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AH-6809 is a prostaglandin E2 receptor antagonist. The compound has been reported to antagonize the anti-aggregatory activity of BW245C, 9 α, 11 β-PGF2, and PGD2. Mouse prostanoid receptor studies reveal that AH-6809 antagonizes the EP1 and EP2 receptors, and does not bind to the EP4 receptor. AH-6809 has been shown to also act on DP1. Both EP1 and DP1 receptors induce and elevate intracellular calcium levels, and have the potential to influence the chloride secretory response. Additionally, studies indicate that AH-6809 is a PGE2 antagonist and that it has a more potent inhibitor than Butaprost (sc-221387), and has been used to study the PAR2 receptor. AH-6809 is an inhibitor of DP2 and EP3.


References

1. Keery, R.J. and Lumley, P. 1988. Br. J. Pharmacol. 94: 745-754. PMID: 2460179
2. Funk, C.D., et al. 1993. J. Biol. Chem. 268: 26767-26772. PMID: 8253813
3. Woodward, D.F., et al. 1995. Biochem. Pharmacol. 50: 1731-1733. PMID: 7503778
4. Kiriyama, M., et al. 1997. Br. J. Pharmacol. 122: 217-224. PMID: 9313928
5. van der Merwe, J.Q., et al. 2009. J. Pharmacol. Exp. Ther. 329: 747-752. PMID: 19190238
6. Rodríguez-Lagunas, M.J., et al. 2010. Am. J. Physiol. 299: C324-C334. PMID: 20484658

Physical State :
Solid
Solubility :
Soluble in ethanol (2.5 mg/ml), DMSO (8 mg/ml), DMF (8 mg/ml), PBS (7.2) (~0.34 mg/ml), 0.1M Na2CO3 (~4 mg/ml), EtOH (~0.5 mg/ml), and 1.1eq. NaOH (100 mM).
Storage :
Store at room temperature
Melting Point :
261-262° C
Boiling Point :
514.23° C at 760 mmHg
Density :
1.33 g/cm3
Refractive Index :
n20D 1.62
Ki Data :
: Ki= 350 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
119461
MDL Number :
MFCD00675065
SMILES :
CC(C)OC1=CC2=C(C=C1)C(=O)C3=C(O2)C=CC(=C3)C(=O)O

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Certificate of Analysis

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AH-6809  Product Citations

See how others have used AH-6809. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 17499749  Kreydiyyeh, SI. et al. 2007. Prostaglandins Other Lipid Mediat. 83: 295-303.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Kreydiyyeh Kreydiyyeh, et. al. (PubMed ID 17499749) treated HepG2 cells with AH-6809 at a concentration of 30 M to determine if prostanoid (EP) receptors were involved; This is in conjunction with TNF- (100 ng/ml) treatment. -SCBT Publication Review
Date published: 2015-02-23
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