AGN 193109 Sodium Salt CAS: 171746-21-7 free base
MF: C28H23NaO2
MW: 414.47

AGN 193109 Sodium Salt (CAS 171746-21-7 free base)

AGN 193109 Sodium Salt | CAS 171746-21-7 free base is rated 5.0 out of 5 by 1.
  • y_2021, m_10, d_27, h_19
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.19
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_210768, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 101ms
  • REVIEWS, PRODUCT
loading
5
1
4
0
3
0
2
0
1
0
Alternate Names: AGN 193109 Sodium Salt is also known as 4-[2-[5,6-Dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenyl]ethynyl]benzoic Acid Sodium Salt
Application: AGN 193109 Sodium Salt is A retinoic acid receptor (RAR) antagonist that potently antagonizes against ATRA-induced transcription in RARα, RARβ, and RARγ transfected CV-1 cells
CAS Number: 171746-21-7 free base
Purity: ≥95%
Molecular Weight: 414.47
Molecular Formula: C28H23NaO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits
loading

AGN 193109 Sodium Salt is a retinoic acid receptor (RAR) antagonist. AGN 193109 Sodium Salt targets all three RAR subtypes with higher affinity than all-trans retinoic acid/ATRA.


References

Johnson, A., et al.: J. Med. Chem., 38, 4764 (1995), Agarwal, C., et al.: J. Biol. Chem., 271, 12209 (1996), Vicent, D., et al.: Mol. Cell Biol., 20, 2158 (2000), Kodaira, Y., et al.: J. Biochem., 132, 327 (2002),

Physical State :
Solid
Solubility :
Soluble in DMSO.
Storage :
Store at -20° C
Melting Point :
246-255° C (lit.)
Boiling Point :
564.46° C at 760 mmHg (Predicted)
Density :
1.22 g/cm3 (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
IC50 :
Retinoic acid receptor gamma: IC50 = 3 nM (human); Retinoic acid receptor beta: IC50 = 20 nM (human); Retinoic acid receptor alpha: IC50 = 31 nM (human)
pK Values :
pKa: 4.08 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
DG8573600
PubChem CID :
MDL Number :
MFCD00943817
SMILES :
CC1=CC=C(C=C1)C2=CCC(C3=C2C=C(C=C3)C#CC4=CC=C(C=C4)C(=O)O)(C)C

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

AGN 193109 Sodium Salt (CAS 171746-21-7 free base)  Product Citations

See how others have used AGN 193109 Sodium Salt (CAS 171746-21-7 free base). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 29 total

PMID: # 33542418  Park, JH.|Kim, J.|Choi, SY.|Lee, B.|Lee, JE.|Park, H.|Moon, JW.|Park, SH.|Lee, JM.|Lee, HS.|Oh, J.| et al. 2021. Sci Rep. 11: 3196.

PMID: # 31840817  Diaz-Hernandez, ME.|Khan, NM.|Trochez, CM.|Yoon, T.|Maye, P.|Presciutti, SM.|Gibson, G.|Drissi, H.| et al. 2020. J Cell Physiol. 235: 5241-5255.

PMID: # 30986261  García-Sánchez, A.|Marcos-Vadillo, E.|Sanz, C.|Estravís, M.|Isidoro-García, M.|Dávila, I.| et al. 2019. PLoS One. 14: e0215086.

PMID: # 29731343  Addison, M. et al. 2018. Dev. Cell. 45: 606-620.e3.

PMID: # 28423611  Sullivan, KE. et al. 2017. Oncotarget. 8: 22325-22343.

PMID: # 29061959  Semrau, S.|Goldmann, JE.|Soumillon, M.|Mikkelsen, TS.|Jaenisch, R.|van Oudenaarden, A.| et al. 2017. Nat Commun. 8: 1096.

PMID: # 27564706  Matsumoto, T.|Mochizuki, W.|Nibe, Y.|Akiyama, S.|Matsumoto, Y.|Nozaki, K.|Fukuda, M.|Hayashi, A.|Mizutani, T.|Oshima, S.|Watanabe, M.|Nakamura, T.| et al. 2016. PLoS ONE. 11: e0162049.

PMID: # 26935534  Persaud, SD. et al. 2016. Scientific reports. 6: 22396.

PMID: # 27025988  Suzuki, A. et al. 2016. Nat Commun. 7: 11056.

PMID: # 27911779  Nakajima, T.|Iguchi, T.|Sato, T.| et al. 2016. Proc Natl Acad Sci U S A. 113: 14354-14359.

Citations 1 to 10 of 29 total

For how long is this product stable after dissolving in DMSO?

Asked by: SCM4
Thank you for your question. We have not tested the stability of this chemical (sc-210768) in solution.
Answered by: Technical Support
Date published: 2017-12-22
  • y_2021, m_10, d_27, h_19CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.19
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_1
  • loc_en_US, sid_210768, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 111ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from Kipp Kipp, JL. et al. (PubMed 21084447) used product sc-210768 (AGN 193109 Sodium Salt), a retinoic acid receptor (RAR) antagonist, and found that it abolished the stimulatory effect of either retinoic acid or activin on granulosa cell proliferation. -SCBT Publication Review
Date published: 2015-03-06
  • y_2021, m_10, d_27, h_19
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.19
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_210768, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 14ms
  • REVIEWS, PRODUCT