Ageladine A, TFAA multipurpose inhibitor and pH-sensitive fluorescent dye

Ageladine A, TFA (CAS 643020-13-7)

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Synonym: (4-(4,5-Dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]-pyridin-2-amine), TFA
Application: A multipurpose inhibitor and pH-sensitive fluorescent dye
CAS Number: 643020-13-7
Molecular Weight: 471.00
Molecular Formula: C10H7Br2N5•C2HF3O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ageladine A, TFA is a pH-sensitive fluorescent dye which can be used for live imaging in acidic organelles, cells, and whole animals due to its non-toxic nature, however there is limited detection in alkaline solutions. Ageladine A, TFA is trapped in cells and organelles via hydrophobic interactions on the inner side of membranes. It exhibits long-term stability due to limited metabolization, which causes slow photobleaching. Ageladine A, TFA is an angiogenesis inhibitor, and also inhibits the matrix metalloproteinases MMP-1, -2, -8, -9, -12, -13 and the kinases Tyk2, Dyrk2, Dyrk1A, and Rsk-1.

Physical State :
Solid
Solubility :
Soluble in DMSO, and methanol.
Storage :
Store at 4° C
Refractive Index :
n20D ~1.83 (Predicted)
Fluoresence :
λex 370 nm, λem 415 nm
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
10089677
SMILES :
C1=CN=C(C2=C1NC(=N2)N)C3=CC(=C(N3)Br)Br

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Certificate of Analysis

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