AG 126Selectively inhibits phosphorylation of ERK 1 and ERK 2

AG 126 (CAS 118409-62-4)

AG 126 | CAS 118409-62-4 is rated 5.0 out of 5 by 1.
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Synonym: Tyrphostin AG 126
Application: Selectively inhibits phosphorylation of ERK 1 and ERK 2
CAS Number: 118409-62-4
Purity: 98%
Molecular Weight: 215.17
Molecular Formula: C10H5N3O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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AG 126 selectively inhibits the phosphorylation of ERK1 and ERK2 at 25-50 μM. It also acts as a cell-permeable inhibitor of lipopolysaccharide (LPS)-induced synthesis of tumor necrosis factor-α (TNF α) and nitric oxide in murine peritoneal macrophages. AG 126 blocks LPS-induced tyrosine phosphorylation of a p42MAPK/ERK2 protein substrate, as well as glucocorticoid-induced COX-2 activity in cells (IC50 = 15.38 μM).


References

1. Novogrodsky, A., et al. 1994. Science. 264: 1319-1322. PMID: 8191285
2. Sármay, G., et al. 1994. Proc. Natl. Acad. Sci. U.S.A. 91: 4140-4144. PMID: 8183883
3. Roifman, C.M., et al. 1992. J. Immunol. 149: 1179-1184. PMID: 1380035

Physical State :
Solid
Solubility :
Soluble in DMSO (25 mg/ml), ethanol (5 mg/ml), DMF (~10 mg/ml), DMSO:PBS (1:1 pH 7.2) (0.5 mg/ml), and water (partly miscible).
Storage :
Store at -20° C
Melting Point :
181-182° C
Boiling Point :
~381.9° C at 760 mmHg (Predicted)
Density :
~1.50 g/cm3 (Predicted)
Refractive Index :
n20D 1.69 (Predicted)
IC50 :
Glucocorticoid-induced COX-2 activity: IC50 = 15.38 M (human amnion cells); epidermal GFRK: IC50 = 450 M; platelet-derived GFRK: IC50 = >100 M
pK Values :
pKa: 5.44 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
2046
MDL Number :
MFCD00236448
SMILES :
C1=CC(=C(C=C1C=C(C#N)C#N)O)[N+](=O)[O-]

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AG 126  Product Citations

See how others have used AG 126. Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 26957211  Lee, SY. et al. 2016. Journal of leukocyte biology. 100: 559-68.

PMID: # 27608299  Ahmad, SF. et al. 2016. Molecular immunology. 78: 65-78.

PMID: # 25261871  Voss, K. et al. 2014. Virology. 468-470: 490-503.

PMID: # 11689702  Guasch G et al. 2001. Mol. Cell. Biol. 21: 8129-8142.

Citations 1 to 4 of 4 total
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Rated 5 out of 5 by from Roifman et al Roifman et al. (PubMed ID 1380035) used AG 126 to inhibit tyrosine kinase in human B lymphocytes. -SCBT Publication Review
Date published: 2015-04-22
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