AG 045572A selective gonadotropin-releasing hormone (GnRH) receptor antagonist

AG 045572 (CAS 263847-55-8)

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Synonym: 5-[5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl-methyl]-N-(2,4,6-trimethoxyphenyl)-2-furancarboxamide
Application: A selective gonadotropin-releasing hormone (GnRH) receptor antagonist
CAS Number: 263847-55-8
Purity: ≥97%
Molecular Weight: 491.62
Molecular Formula: C30H37NO5
* Refer to Certificate of Analysis for lot specific data (including water content).
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AG 045572 is a selective gonadotropin-releasing hormone (GnRH) receptor antagonist (Ki = 2.2, 3.8, and 6.0 nM for mouse, rat, and human receptors, respectively).


References

1. Iatsimirskaia, E.A., et al. 2002. Pharm. Res. 19: 202-208. PMID: 11883648
2. Anderes, K.L., et al. 2003. J. Pharmacol. Exp. Ther. 305: 688-695. PMID: 12606616

Physical State :
Solid
Solubility :
Soluble to 100 mM in DMSO and to 50 mM in Ethanol
Storage :
Store at room temperature
Melting Point :
264.68° C (Predicted)
Boiling Point :
~558.2° C at 760 mmHg (Predicted)
Density :
~1.1 g/cm3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9957278
SMILES :
CC1=C(C=C2C(=C1)C(CCC2(C)C)(C)C)CC3=CC=C(O3)C(=O)NC4=C(C=C(C=C4OC)OC)OC

Download SDS (MSDS)

Certificate of Analysis

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