AF-DX 116 (CAS 102394-31-0)

(0)

Alternate Names: 11-[[2-[(Diethylamino)methyl]-1-piperidinyl]acetyl]-5,1 1-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one; Otenzepad

Application: AF-DX 116 is a selective mAChR M2 antagonist

CAS Number: 102394-31-0

Molecular Weight: 421.54

Molecular Formula: C₂₄H₃₁N₅O₂

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data (including water content).

QUICK LINKS

Click on image or enlarge button to enlarge

AF-DX 116 is a selective mAChR M2 antagonist. Ki values are 64, 417, 786, 211 and 5130 nM for human recombinant M2, M1, M3, M4 and M5 muscarinic receptors, respectively.

Physical State :

Solid

Solubility :

Soluble in DMSO (5 mg/ml).

Storage :

Store at room temperature

Melting Point :

221-223° C

Boiling Point :

~573.2° C at 760 mmHg (Predicted)

Density :

~1.2 g/cm³ (Predicted)

Refractive Index :

n²⁰_D 1.58 (Predicted)

IC50 :

mAChR M2: IC₅₀ = 50 nM (rat); mAChR M3: IC₅₀ = 6 µM (rat)

Ki Data :

mAChR M2: K_i= 64 nM; mAChR M4: K_i= 0.21 µM; mAChR M1: K_i= 0.42 µM; mAChR M3: K_i= 0.79 µM; mAChR M5: K_i= 5.13 µM

pK Values :

pK_a: 11.29 (Predicted), pK_b: 10.46 (Predicted)

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

RTECS :

UV0697000

PubChem CID :

107867

MDL Number :

MFCD00864743

SMILES :

CCN(CC)CC1CCCCN1CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents