AF-DX 116 CAS: 102394-31-0
MF: C24H31N5O2
MW: 421.54
A selective mAChR M2 antagonist.

AF-DX 116 (CAS 102394-31-0)

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Alternate Names: 11-[[2-[(Diethylamino)methyl]-1-piperidinyl]acetyl]-5,1 1-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one; Otenzepad
Application: AF-DX 116 is a selective mAChR M2 antagonist
CAS Number: 102394-31-0
Molecular Weight: 421.54
Molecular Formula: C24H31N5O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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AF-DX 116 is a selective mAChR M2 antagonist. Ki values are 64, 417, 786, 211 and 5130 nM for human recombinant M2, M1, M3, M4 and M5 muscarinic receptors, respectively.

Physical State :
Solid
Solubility :
Soluble in DMSO (5 mg/ml).
Storage :
Store at room temperature
Melting Point :
221-223° C
Boiling Point :
~573.2° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.58 (Predicted)
IC50 :
mAChR M2: IC50 = 50 nM (rat); mAChR M3: IC50 = 6 µM (rat)
Ki Data :
mAChR M2: Ki= 64 nM; mAChR M4: Ki= 0.21 µM; mAChR M1: Ki= 0.42 µM; mAChR M3: Ki= 0.79 µM; mAChR M5: Ki= 5.13 µM
pK Values :
pKa: 11.29 (Predicted), pKb: 10.46 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
UV0697000
PubChem CID :
MDL Number :
MFCD00864743
SMILES :
CCN(CC)CC1CCCCN1CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4

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Certificate of Analysis

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AF-DX 116 (CAS 102394-31-0)  Product Citations

See how others have used AF-DX 116 (CAS 102394-31-0). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 27576172  Liang, Z. et al. 2017. Neurourol. Urodyn. 36: 1261-1269.

PMID: # 25412212  Dai, Y. et al. 2015. Molecular medicine reports. 11: 2292-8.

Citations 1 to 2 of 2 total
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