Molecular structure of Adrenic Acid (22:4, n-6), CAS Number: 28874-58-0
Adrenic Acid (22:4, n-6) (CAS 28874-58-0)
See product citations (2)
Alternate Names:
cis-7,10,13,16-Docosatetraenoic acid
Application:
Adrenic Acid (22:4, n-6) is a polyunsaturated fatty acid believed to be a source of arachidonic acid
CAS Number:
28874-58-0
Purity:
≥96%
Molecular Weight:
332.5
Molecular Formula:
C22H36O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Adrenic Acid (22-4,n-6), also known as 7,10,13,16-Docosatetraenoic acid, is a polyunsaturated fatty acid. Peroximal beta-oxidation of Adrenic Acid (22:4, n-6) may act to form arachidonic acid. Endothelial cells have been shown to convert arachidonic acid to docosatetraenoic acid and releasing docosatetraenoic acid when exposed to ionophore A23187 (sc-3591). Additionally, endothelial cell studies have demonstrated that adrenic acid reduces prostaglandin 12.
Adrenic Acid (22:4, n-6) (CAS 28874-58-0) References
- Lipids in blood-brain barrier models in vitro II: Influence of glial cells on lipid classes and lipid fatty acids. | Krämer, SD., et al. 2002. In Vitro Cell Dev Biol Anim. 38: 566-71. PMID: 12762838
- Identification of two novel microalgal enzymes involved in the conversion of the omega3-fatty acid, eicosapentaenoic acid, into docosahexaenoic acid. | Pereira, SL., et al. 2004. Biochem J. 384: 357-66. PMID: 15307817
- Priming effect of adrenic acid (22:4(n-6)) on tissue factor activity expressed by thrombin-stimulated endothelial cells. | Tardy, B., et al. 1992. Atherosclerosis. 95: 51-8. PMID: 1642692
- Arachidonate-derived dihomoprostaglandin production observed in endotoxin-stimulated macrophage-like cells. | Harkewicz, R., et al. 2007. J Biol Chem. 282: 2899-910. PMID: 17135246
- Chronic risperidone normalizes elevated pro-inflammatory cytokine and C-reactive protein production in omega-3 fatty acid deficient rats. | McNamara, RK., et al. 2011. Eur J Pharmacol. 652: 152-6. PMID: 21118685
- Adrenoleukodystrophy. The chain shortening of erucic acid (22:1(n-9)) and adrenic acid (22:4(n-6)) is deficient in neonatal adrenoleukodystrophy and normal in X-linked adrenoleukodistrophy skin fibroblasts. | Christensen, E., et al. 1989. Biochim Biophys Acta. 1002: 79-83. PMID: 2538146
- Evidence for peroxisomal retroconversion of adrenic acid (22:4(n-6)) and docosahexaenoic acids (22:6(n-3)) in isolated liver cells. | Hagve, TA. and Christophersen, BO. 1986. Biochim Biophys Acta. 875: 165-73. PMID: 2935195
- Exposure to a Farm Environment During Pregnancy Increases the Proportion of Arachidonic Acid in the Cord Sera of Offspring. | Barman, M., et al. 2019. Nutrients. 11: PMID: 30678238
- Docosatetraenoic acid in endothelial cells: formation, retroconversion to arachidonic acid, and effect on prostacyclin production. | Mann, CJ., et al. 1986. Arch Biochem Biophys. 244: 813-23. PMID: 3080955
- The Zellweger syndrome: deficient chain-shortening of erucic acid (22:1 (n-9)) and adrenic acid (22:4 (n-6)) in cultured skin fibroblasts. | Christensen, E., et al. 1988. Biochim Biophys Acta. 959: 134-42. PMID: 3349094
- Synthesis of dihomoprostaglandins from adrenic acid (7,10,13,16-docosatetraenoic acid) by human endothelial cells. | Campbell, WB., et al. 1985. Biochim Biophys Acta. 837: 67-76. PMID: 3931686
- Arachidonic acid formed by peroxisomal beta-oxidation of 7,10,13,16-docosatetraenoic acid is esterified into 1-acyl-sn-glycero-3-phosphocholine by microsomes. | Baykousheva, SP., et al. 1994. J Biol Chem. 269: 18390-4. PMID: 8034586
- Fate of linoleic, arachidonic, and docosa-7,10,13,16-tetraenoic acids in rat testicles. | Ayala, S., et al. 1973. J Lipid Res. 14: 296-305. PMID: 9704073
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Adrenic Acid (22:4, n-6), 25 mg | sc-200784 | 25 mg | $209.00 | |||
Adrenic Acid (22:4, n-6), 100 mg | sc-200784A | 100 mg | $639.00 |