ADP-HPD ammonium salt dihydrateA potent, noncompetitive and specific inhibitor of poly(ADP-ribose) glycohydrolase

ADP-HPD ammonium salt dihydrate

ADP-HPD ammonium salt dihydrate is rated 5.0 out of 5 by 1.
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Synonym: Adenosine 5'-diphosphate (Hydroxymethyl)pyrrolidinediol, NH4
Application: A potent, noncompetitive and specific inhibitor of poly(ADP-ribose) glycohydrolase
Purity: ≥95%
Molecular Weight: 595.3
Molecular Formula: C15H23N6O12P2•NH42H2O
* Refer to Certificate of Analysis for lot specific data (including water content).
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A potent, noncompetitive and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG) (IC50=120nM) versus ADP-ribose (IC50=120µM). This compound does not affect the activities of either PARP-1 or NAD:arginine mono(ADP-ribosyl)-transferase A even at 1mM concentration.


References

J.T. Slama, et al.; J. Med. Chem. 38, 389 (1995) J.T. Slama, et al.; J. Med. Chem. 38, 4332 (1995) S. Vispe, et al.; PNAS 97, 9886 (2000)

Usage :
Following reconstitution, prepare aliquots and store at -20°C.
Physical State :
Solid
Solubility :
Soluble in water (5 mg/ml).
Storage :
Store at -20° C
IC50 :
poly(ADP-ribose) glycohydrolase: IC50 = 120 nM; ADP-ribose: IC50 = 120 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
MDL Number :
MFCD08702714

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Certificate of Analysis

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ADP-HPD ammonium salt dihydrate  Product Citations

See how others have used ADP-HPD ammonium salt dihydrate. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 31616951  Nucleic Acids Res. 47: 8502-8520.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Vilchez Larrea Vilchez Larrea, SC. Et al. (PubMed 23776710) used the potent, noncompetitive and specific inhibitor of poly(ADP-ribose) glycohydrolase ADP-HPD to demonstrate that host cell poly(ADP-ribose) glycohydrolase is critical for Trypanosoma cruzi infection cycle. -SCBT Publication Review
Date published: 2015-07-04
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