ADH6 Antibody (WW32): sc-100495

ADH6 Antibody (WW32) is a mouse monoclonal IgG2a kappa light chain antibody that detects ADH6 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-ADH6 antibody (WW32) is available as the non-conjugated format. ADH6, also known as alcohol dehydrogenase 6 or ADH-5, is a 368 amino acid enzyme belonging to the class V zinc-containing alcohol dehydrogenase family, which plays a crucial role in metabolizing various substrates, including retinol, hydroxysteroids, ethanol, aliphatic alcohols, and lipid peroxidation products. ADH6 is primarily localized in the cytoplasm and predominantly expressed in the stomach and liver, where ADH6 catalyzes the reversible oxidation of alcohols to corresponding aldehydes or ketones, utilizing two zinc ions as essential cofactors. A glucocorticoid response element upstream of ADH6′s 5′ untranslated region indicates that expression may be regulated by hormonal signals, highlighting potential roles in metabolic processes influenced by steroid hormones. Multiple isoforms of ADH6 exist due to alternative splicing events, suggesting complex regulation of function, which may have implications for understanding individual variations in alcohol metabolism and related disorders.

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ADH6 Antibody (WW32) References:

1. Mammalian alcohol dehydrogenase of higher classes: analyses of human ADH5 and rat ADH6.  |  Höög, J., et al. 2001. Chem Biol Interact. 130-132: 395-404. PMID: 11306061
2. A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity.  |  Osier, MV., et al. 2002. Am J Hum Genet. 71: 84-99. PMID: 12050823
3. The mammalian alcohol dehydrogenases interact in several metabolic pathways.  |  Höög, JO., et al. 2003. Chem Biol Interact. 143-144: 175-81. PMID: 12604202
4. Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence.  |  Luo, X., et al. 2006. Am J Hum Genet. 78: 973-87. PMID: 16685648
5. Multiple ADH genes modulate risk for drug dependence in both African- and European-Americans.  |  Luo, X., et al. 2007. Hum Mol Genet. 16: 380-90. PMID: 17185388
6. Enzymatic properties of the protein encoded by newly cloned human alcohol dehydrogenase ADH6 gene.  |  Chen, CS. and Yoshida, A. 1991. Biochem Biophys Res Commun. 181: 743-7. PMID: 1755855
7. A human alcohol dehydrogenase gene (ADH6) encoding an additional class of isozyme.  |  Yasunami, M., et al. 1991. Proc Natl Acad Sci U S A. 88: 7610-4. PMID: 1881901

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ADH6 Antibody (WW32) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-ADH6 Antibody (WW32) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ADH6 Antibody (WW32) Specifications

Alternate Product Name: ADH6

Product Clone Name: WW32

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 55-145

Epitope Target: ADH6

Epitope Species: human

Product Reactivity/Detection: ADH6

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for ADH6 Antibody (WW32): N/A