AdenosineAn apoptosis inducer and an Adenosine A Receptor activator

Adenosine (CAS 58-61-7)

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Synonym: 9-β-D-Ribofuranosyladenine; Adenine riboside; Adenine-9-β-D-ribofuranoside
Application: An apoptosis inducer and an Adenosine A Receptor activator
CAS Number: 58-61-7
Purity: ≥99%
Molecular Weight: 267.24
Molecular Formula: C10H13N5O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Adenosine induces apoptosis in human leukemia HL-60 cells. It also has anti-arrhythmic properties. Adenosine is a neurotransmitter that acts as the preferred endogenous agonist at all Adenosine A Receptor subtypes. Adenosine is an activator of Adenosine A2A-R and Adenosine A1-R.


References

1. Tanaka, Y., et al. 1994. Exp. Cell Res. 213: 242-252. PMID: 8020596

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in 1M NH4OH, water (7 mg/ml), and DMSO (75 mM). Insoluble in ethanol.
Storage :
Store at 4° C
Melting Point :
234-236° C (lit.)
Boiling Point :
~676.3° C at 760 mmHg (Predicted)
Density :
~2.1 g/cm3 (Predicted)
Refractive Index :
n20D 1.91 (Predicted)
Optical Activity :
α20/D -70°, c = 2 in 5% NaOH
IC50 :
Adenosine A1 receptor: EC5050 = 0.31 µM (CHO cells); ADP induced blood platelet aggregation: IC50 = 2.5 µM (human); PKA at 100 uM ATP: IC50 = 160 µM; Adenosine A2a receptor: IC50 = 150 nM (Rattus norvegicus); Canis familiaris: EC5050 = 0.12 nM (Canis lupus familiaris)
Ki Data :
Adenosine A2b receptor: Ki= 5 nM (Rattus norvegicus); Adenosine A1 receptor: Ki= 5.1 nM (Rattus norvegicus); Adenosine A2a receptor: Ki= 20 nM (human); Adenosine A2a receptor: Ki= 5 nM (Rattus norvegicus)
pK Values :
pKa: 3.5, 12.5, pKb: 10.74
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
AU7175000
PubChem CID :
60961
Merck Index :
14,153
MDL Number :
MFCD00005752
EC Number :
200-389-9
Beilstein Registry :
93029
SMILES :
C1=NC2=C(C(=N1)N)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O

Download SDS (MSDS)

Certificate of Analysis

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Is this Cell Culture grade?

Asked by: Io5ay
Thank you for your question. This item is not normally cell culture grade, but we can make a special version of cell culture grade for this product. Contact specialorders@scbt.com. Additionally, please contact Technical Service if you have further questions concerning this product.
Answered by: Tech Service 9
Date published: 2016-12-15
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