AdefovirAn antiviral compound

Adefovir (CAS 106941-25-7)

Adefovir | CAS 106941-25-7 is rated 5.0 out of 5 by 1.
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Synonym: P-[[2-(6-Amino-9H-purin-9-yl)ethoxy]methyl]phosphonic Acid; PMEA, GS-393, 9-(2-Phosphonylmethoxyethyl)adenine; [[2-(6-Amino-9H-purin-9-yl)ethoxy]methyl]phosponic Acid
Application: An antiviral compound
CAS Number: 106941-25-7
Purity: ≥98%
Molecular Weight: 273.19
Molecular Formula: C8H12N5O4P
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Used as an antiviral.


References

Cundy, K.C., et al.: Antimicrob. Ag. Chemother., 39, 2401 (1995), Naesens, L. et al.: Antiviral Chem. Chemother., 8, 1 (1997), Kahn, J., et al.: J. Am. Med. Assoc., 282, 2305 (1999),

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in hot water, and 0.1 M NaOH (≥5 mg/ml).
Storage :
Store at -20° C
Melting Point :
>250° C
Density :
1.88
Refractive Index :
n20D 1.77 (Predicted)
IC50 :
Human herpesvirus 5: IC50 = 0.1 nM (human); Moloney murine sarcoma virus: IC50 = 2 µg/ml (Moloney murine sarcoma virus)
Ki Data :
Phosphoribosyl pyrophosphate synthetase-associated protein 2: Ki= 3000 µM (human)
pK Values :
pKa: 1.63, pKb: 4.19
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
SZ6563500
PubChem CID :
60172
MDL Number :
MFCD00866943
SMILES :
C1=NC2=C(C(=N1)N)N=CN2CCOCP(=O)(O)O

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Certificate of Analysis

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Adefovir  Product Citations

See how others have used Adefovir. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 26779022  Mandíková, J. et al. 2015. Frontiers in pharmacology. 6: 304.

PMID: # 24436471  Park, J. et al. 2014. J. Am. Soc. Nephrol. 25: 726-36.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Wen Wen, Z. et al. (PubMed 25237370) focused on the effect of hepatitis B (HBV) genotypes on antiviral efficacy of Adefovir. HBV genotypes B and C had no significant difference in virologic, biochemical, and immunologic response to Adefovir. -SCBT Publication Review
Date published: 2015-07-18
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