ADAMTS-5 Inhibitor CAS: 929634-33-3
MF: C16H11ClF3N3OS3
MW: 449.9
A Zn2+ chelating thioxothiazolidinone.

ADAMTS-5 Inhibitor (CAS 929634-33-3)

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Alternate Names: 5-((4-Chlorobenzylthio-3-trifluoromethyl-N-methyl-1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one
Application: ADAMTS-5 Inhibitor is a Zn2+ chelating thioxothiazolidinone
CAS Number: 929634-33-3
Molecular Weight: 449.9
Molecular Formula: C16H11ClF3N3OS3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

ADAMTS-5 Inhibitor is a thioxothiazolidinone compound that possesses a Zn2+-chelating structural motif and acts as an ADAMTS-5 (aggrecanase-2) inhibitor (IC50 = 1.1 μM) with ~40-fold selectivity over ADAMTS-4 (aggrecanase-1).


References

Bursavich, M.G., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1185. Gilbert, A.M., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1189.

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml).
Storage :
Store at -20° C
Density :
~1.6 g/cm3 (Predicted)
IC50 :
ADAMTS-5 : IC50 = 1.1 µM
pK Values :
pKa: 6.69 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16664963
SMILES :
CN1C(=C(C(=N1)C(F)(F)F)/C=C\\2/C(=O)NC(=S)S2)SCC3=CC=C(C=C3)Cl

Download SDS (MSDS)

Certificate of Analysis

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