Acyclovir is an antiviral compound that can be used to induce apoptosis in cells transfected with herpes simplex virus thymidine kinase (HSV-TK). The compound may exert inhibitory effects through the alterations of the cell cycle in leukemia cells lines, such as p185BCR-ABL expressing OM9:22 cells, by synchronizing the G0/G1 phase. Formation of acycloguanosine triphosphate occurs through the phosphorylation of HSV-TK and can inhibit the viral DNA polymerase. Acyclovir also has the ability to inhibit the proliferation of the fibroblast cells, NIH 3T3, transformed with v-abl or bcr-abl.
1. Ochiai, H., et al. 1992. Antiviral Res. 17: 1-16. PMID: 1310580 2. Cioé, L., et al. 1992. J. Biol. Chem. 267: 22178-22182. PMID: 1331046 3. Whitley, R.J. and Gnann, J.W. 1992. N. Engl. J. Med. 327: 782-789. PMID: 1288525 4. Nishimaki, J., et al. 1996. Leuk. Res. 20: 415-420. PMID: 8683981 5. Tong, X.W., et al. 1998. Anticancer Res. 18: 713-718. PMID: 9615710 6. Rubsam, L.Z., et al. 1998. Cancer Res. 58: 3873-3882. PMID: 9731497 6. Kuo, Y.C. et al. 2002. Antimicrob. Agents Chemother. 46(9): 2854-2864. PMID: 12183238
Soluble in water (partly), DMSO (4.5 mg/ml), DMF (1 mg/ml), 1eq. HCl (50 mM), and dilute alkalies.
bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of
Relevant assays for usage as analytical standardsRelevant assays for usage as analytical standards.
Date published: 2015-06-08
Rated 5 out of
KuoKuo, YC. et al. (PubMed 12183238) used Acyclovir, an antiviral compound, as a positive control in Vero cell cultures infected with HSV-1. Acyclovir performed as expected in inhibiting HSV-1 replication. -SCBT Publication Review
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
Create a new account
Email address already exists, please enter a new valid email address.Hide
USE YOUR SOCIAL NETWORK
Create an account quickly and easily with your preferred social network account. You won't have to remember an extra name and password.
Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.