Acridine Orange hemi(zinc chloride) salt CAS: 10127-02-3
MF: C17H19ClN3•HCl•1/2ZnCl2
MW: 369.96
Fluorescent dye that stains DNA and RNA.

Acridine Orange hemi(zinc chloride) salt (CAS 10127-02-3)

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Alternate Names: 3,6-Bis(dimethylamino)acridinium chloride hemi(zinc chloride salt)
Application: Acridine Orange hemi(zinc chloride) salt is fluorescent dye that stains DNA and RNA
CAS Number: 10127-02-3
Molecular Weight: 369.96
Molecular Formula: C17H19ClN3•HCl•1/2ZnCl2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Acridine Orange hemi (zinc chloride) salt is a cell-permeable metachromatic fluorescent dye that stains DNA and RNA. This dye is also an inhibitor of RNA polymerase.


References

1. Wolfe, A.D. et al. 1972. Biochemistry. 11(9): 1569-1572. PMID: 4554949
2. Golden, J.F. and West, S.S. 1974. J. Histochem. Cytochem. 22(7): 495-505. PMID: 4136741
3. Golden, J.F. et al. 1979. J. Histochem. Cytochem. 27(1): 522-528. PMID: 374619
4. Frost, J.K. et al. 1979. J. Histochem. Cytochem. 27(1): 545-551. PMID: 86575
5. Tyrer, H.W. et al. 1979. J. Histochem. Cytochem. 27(1): 552-556. PMID: 86576
6. Paul, R.N. 1980. Stain Technol. 55(3): 195-196. PMID: 6161450

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (1 mg/ml).
Storage :
Store at room temperature
Melting Point :
165° C
Refractive Index :
n20D ~1.71 (Predicted)
Fluoresence :
λex 502 nm, λem 525 nm; λex 460 nm, λem 650 nm
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
AR7600000
PubChem CID :
MDL Number :
MFCD00081043
EC Number :
233-353-6
Beilstein Registry :
3734978
SMILES :
CN(C)C1=CC2=C(C=C1)C=C3C=CC(=CC3=N2)N(C)C.Cl.[Cl-].[Cl-].[Zn+2]

Download SDS (MSDS)

Certificate of Analysis

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I am looking for a reference reporting the action of Acridine Orange as RNA synthesis inhibitor. I'm also interested to know whether it has any effect on DNA synthesis. Thanks!

Asked by: Anonymous
Thank you for your question. We found the following article referring to both RNA and DNA, and we hope this information is helpful. Simultaneous staining of ribonucleic and deoxyribonucleic acids in unfixed cells using acridine orange in a flow cytofluorometric system. Traganos F The Journal of Histochemistry and Cytochemistry 25(1), 46-56, (1977)
Answered by: Technical Support
Date published: 2020-03-26
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