AcitretinA synthetic retinoid - the major metabolite of etretinate

Acitretin (CAS 55079-83-9)

Acitretin | CAS 55079-83-9 is rated 5.0 out of 5 by 1.
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Synonym: Neotigason; Soriatane
Application: A synthetic retinoid - the major metabolite of etretinate
CAS Number: 55079-83-9
Purity: ≥99%
Molecular Weight: 326.43
Molecular Formula: C21H26O3
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Acitretin is a synthetic retinoid, the major metabolite of etretinate (sc-205689). It has demonstrated an ability to suppress the development of chemically-induced epithelial tumors, as well as squamous cell carcinoma.


References

1. Liu, Xin., et al., 2008. Comparison of the in vitro and in vivo effects of retinoids either alone or in combination with cisplatin and 5-fluorouracil on tumor development and metastasis of melanoma. Cancer chemotherapy and pharmacology. 63(1): 167-74. PMID: 18465132
2. Sato, Tomohiro., et al., 2008. In silico functional profiling of small molecules and its applications. Journal of medicinal chemistry. 51(24): 7705-16. PMID: 19032081

Physical State :
Solid
Solubility :
Soluble in Warm Chloroform
Storage :
Store at -80° C
Melting Point :
228-230°C (lit.)(dec.)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5284513
SMILES :
CC1=CC(=C(C(=C1/C=C/C(=C/C=C/C(=C/C(=O)O)/C)/C)C)C)OC

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Certificate of Analysis

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Acitretin  Product Citations

See how others have used Acitretin. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 26385866  Warkus, EL. et al. 2016. Toxicol. Sci. 149: 15-30.

Citations 1 to 1 of 1 total

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. The compound, sc-210754, is provided as a yellow or greenish-yellow crystalline powder. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-02-14
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Rated 5 out of 5 by from Holthoewer Holthoewer, D. et al. (PubMed 22301853) reported that Acitretin, an enhancer of -secretase expression, crosses the blood-brain barrier and is not eliminated by P-glycoprotein. -SCBT Publication Review
Date published: 2015-02-25
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