Date published: 2025-10-15

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Acetaldehyde-d4 (CAS 1632-89-9)

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Alternate Names:
Tetradeuteroacetaldehyde; 1,2,2,2-tetradeuterioethanone
Application:
Acetaldehyde-d4 is a derivatizing agent to measure endogenous epinephrine and norepinephrine in human plasma
CAS Number:
1632-89-9
Molecular Weight:
48.08
Molecular Formula:
C2D4O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.

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Acetaldehyde-d4 is a deuterated form of acetaldehyde, a colorless, flammable liquid with a pungent, fruity odor. In development, acetaldehyde-d4 is used as a stable isotope-labeled compound for various applications such as tracer studies, isotopic labeling, and metabolic. Its mechanism of action involves serving as a labeled compound for nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry, allowing for the tracking and analysis of metabolic pathways and chemical reactions. Acetaldehyde-d4 is designed to replace non-deuterated acetaldehyde in experimental applications, providing with a labeled form of the compound for precise and accurate analysis of metabolic processes and chemical reactions at the molecular level. This labeled compound is particularly useful in studies that require the identification and quantification of acetaldehyde and its derivatives in complex biological and chemical systems, enabling to gain insights into metabolic fluxes and pathways without interference from non-labeled compounds.


Acetaldehyde-d4 (CAS 1632-89-9) References

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  2. The Strecker synthesis as a source of amino acids in carbonaceous chondrites: deuterium retention during synthesis.  |  Lerner, NR., et al. 1993. Geochim Cosmochim Acta. 57: 4713-23. PMID: 11539581
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  4. Dipole enhancement of positron binding to molecules.  |  Danielson, JR., et al. 2010. Phys Rev Lett. 104: 233201. PMID: 20867236
  5. Simple derivatization of aldehydes with D-cysteine and their determination in beverages by liquid chromatography-tandem mass spectrometry.  |  Kim, HJ. and Shin, HS. 2011. Anal Chim Acta. 702: 225-32. PMID: 21839202
  6. Ultra sensitive measurement of endogenous epinephrine and norepinephrine in human plasma by semi-automated SPE-LC-MS/MS.  |  Zhang, G., et al. 2012. J Chromatogr B Analyt Technol Biomed Life Sci. 895-896: 186-90. PMID: 22483332
  7. Addressing the need for biomarker liquid chromatography/mass spectrometry assays: a protocol for effective method development for the bioanalysis of endogenous compounds in cerebrospinal fluid.  |  Benitex, Y., et al. 2013. Rapid Commun Mass Spectrom. 27: 1882-6. PMID: 23857934
  8. The impact of carbon-13 and deuterium on relative quantification of proteins using stable isotope diethyl labeling.  |  Koehler, CJ., et al. 2015. Rapid Commun Mass Spectrom. 29: 830-6. PMID: 26377011
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  12. Prebiotic Synthesis and Isomerization in Interstellar Analog Ice: Glycinal, Acetamide, and Their Enol Tautomers.  |  Marks, JH., et al. 2023. Angew Chem Int Ed Engl. 62: e202218645. PMID: 36702757
  13. Tetrahydro-beta-carbolines in human urine and rat brain--no evidence of formation by alcohol drinking.  |  Matsubara, K., et al. 1986. Alcohol Alcohol. 21: 339-45. PMID: 3814252
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Acetaldehyde-d4, 1 g

sc-227183
1 g
$133.00
US: Only available in the US