Ac-YVAD-pNA CAS: 149231-66-3
MF: C29H36N6O10
MW: 628.63
A substrate for caspase-1 and caspase-4; cleavage is monitored colorimetrically at 405nm.

Ac-YVAD-pNA (CAS 149231-66-3)

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Alternate Names: Caspase-1 Substrate IV, Colorimetric
Application: Ac-YVAD-pNA is a substrate for caspase-1 and caspase-4; cleavage is monitored colorimetrically at 405nm
CAS Number: 149231-66-3
Purity: ≥97%
Molecular Weight: 628.63
Molecular Formula: C29H36N6O10
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ac-YVAD-pNA is a substrate for caspase-1 and caspase-4. The sequence is a modification of pro-interleukin-1β Asp-116 cleavage site for caspase-1. It is similar to Ac-YVAD-AMC but cleavage is monitored colorimetrically at 405nm.


References

1. Thornberry, N.A., et al. 1992. Nature. 356: 768-774. PMID: 1574116
2. Reiter, L.A. 1994. Int. J. Pept. Protein Res. 43: 87-86. PMID: 8138355
3. Thornberry, N.A. 1994. Meth. Enzymol. 244: 615-63. PMID: 7845238

Appearance :
Powder
Physical State :
Solid
Sequence :
Ac-Tyr-Val-Ala-Asp-pNA (pNA=p-Nitroaniline)
Solubility :
Soluble in DMSO (10 mM), and water (partly miscible).Dilute with buffer (pH 7.5).
Storage :
Store at -20° C
Boiling Point :
~1108.93° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.61 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :
MFCD00274387
SMILES :
C[[email protected]@H](C(=O)N[[email protected]@H](CC(=O)O)C(=O)NC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)[[email protected]](C(C)C)NC(=O)[[email protected]](CC2=CC=C(C=C2)O)NC(=O)C

Download SDS (MSDS)

Certificate of Analysis

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Ac-YVAD-pNA (CAS 149231-66-3)  Product Citations

See how others have used Ac-YVAD-pNA (CAS 149231-66-3). Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 33833547  Read, SA.|Gloss, BS.|Liddle, C.|George, J.|Ahlenstiel, G.| et al. 2021. J Inflamm Res. 14: 1257-1270.

PMID: # 30795621  Nováková, J.|Talacko, P.|Novák, P.|Vališ, K.| et al. 2019. Cells. 8:

PMID: # 29366909  Gehrke, N.|Hövelmeyer, N.|Waisman, A.|Straub, BK.|Weinmann-Menke, J.|Wörns, MA.|Galle, PR.|Schattenberg, JM.| et al. 2018. J. Hepatol. 68: 986-995.

PMID: # 24722332  Jearaphunt, M.|Noonin, C.|Jiravanichpaisal, P.|Nakamura, S.|Tassanakajon, A.|Söderhäll, I.|Söderhäll, K.| et al. 2014. PLoS Pathog. 10: e1004059.

PMID: # 32332700  Cell Death Dis. 11: 277.

Citations 1 to 5 of 5 total
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