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Ac-YVAD-pNA is a substrate for caspase-1 and caspase-4. The sequence is a modification of pro-interleukin-1β Asp-116 cleavage site for caspase-1. It is similar to Ac-YVAD-AMC but cleavage is monitored colorimetrically at 405nm.
1. Thornberry, N.A., et al. 1992. Nature. 356: 768-774. PMID: 1574116
2. Reiter, L.A. 1994. Int. J. Pept. Protein Res. 43: 87-86. PMID: 8138355
3. Thornberry, N.A. 1994. Meth. Enzymol. 244: 615-63. PMID: 7845238
See how others have used Ac-YVAD-pNA. Click on the entry to view the PubMed entry .
PMID: # 30795621 Nováková, J.|Talacko, P.|Novák, P.|Vališ, K.| et al. 2019. Cells. 8:
PMID: # 29366909 Gehrke, N.|Hövelmeyer, N.|Waisman, A.|Straub, BK.|Weinmann-Menke, J.|Wörns, MA.|Galle, PR.|Schattenberg, JM.| et al. 2018. J. Hepatol. 68: 986-995.
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