Ac-YVAD-AFC CAS: 219137-85-6
MF: C33H36F3N5O10
MW: 719.67
A fluorogenic substrate for caspase-1 and caspase-4.

Ac-YVAD-AFC (CAS 219137-85-6)

Ac-YVAD-AFC | CAS 219137-85-6 is rated 5.0 out of 5 by 1.
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Alternate Names: Ac-Tyr-Val-Ala-Asp-AFC; Caspase-1 substrate (fluorogenic), Caspase-4 substrate (fluorogenic)
Application: Ac-YVAD-AFC is a fluorogenic substrate for caspase-1 and caspase-4
CAS Number: 219137-85-6
Purity: ≥97%
Molecular Weight: 719.67
Molecular Formula: C33H36F3N5O10
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ac-YVAD-AFC is a fluorogenic substrate for caspase-1 and caspase-4.


References

1. Marcelli, M., et al. 1998. Cancer Res. 58: 76-83. PMID: 9426061

Appearance :
Powder
Physical State :
Solid
Sequence :
Ac-Tyr-Val-Ala-Asp-AFC (AFC=7-Amino-4-trifluoromethylcoumarin)
Solubility :
Soluble in DMSO.
Storage :
Desiccate at -20° C
Boiling Point :
1084.64° C at 760 mmHg (Predicted)
Density :
1.42 g/cm3 (Predicted)
Refractive Index :
n20D 1.59 (Predicted)
Fluoresence :
λex 400 nm, λem 505 nm
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :
MFCD01318881
SMILES :
C[[email protected]@H](C(=O)N[[email protected]@H](CC(=O)O)C(=O)NC1=CC2=C(C=C1)C(=CC(=O)O2)C(F)(F)F)NC(=O)[[email protected]](C(C)C)NC(=O)[[email protected]](CC3=CC=C(C=C3)O)NC(=O)C

Download SDS (MSDS)

Certificate of Analysis

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Ac-YVAD-AFC (CAS 219137-85-6)  Product Citations

See how others have used Ac-YVAD-AFC (CAS 219137-85-6). Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 33691097  Bambouskova, M.|Potuckova, L.|Paulenda, T.|Kerndl, M.|Mogilenko, DA.|Lizotte, K.|Swain, A.|Hayes, S.|Sheldon, RD.|Kim, H.|Kapadnis, U.|Ellis, AE.|Isaguirre, C.|Burdess, S.|Laha, A.|Amarasinghe, GK.|Chubukov, V.|Roddy, TP.|Diamond, MS.|Jones, RG.|Simons, DM.|Artyomov, MN.| et al. 2021. Cell Rep. 34: 108756.

PMID: # 33324059  Neuropsychiatr Dis Treat. 2975-2987.

PMID: # 30232261  Proc. Natl. Acad. Sci. U.S.A. 115: E9381-E9390.

Citations 1 to 3 of 3 total
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Rated 5 out of 5 by from Marks N; et al Marks N; et al. (PubMed ID: 9590441) determined that Ac-YVAD-AFC (a preferred substrate for caspase-1) did not increase the activity of caspase-3 in rat cerebellar granule cells exposed to apoptotic conditions. -SCBT Publication Review
Date published: 2015-02-15
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