Ac-YVAD-AFCA fluorogenic substrate for caspase-1 and caspase-4

Ac-YVAD-AFC (CAS 219137-85-6)

Ac-YVAD-AFC | CAS 219137-85-6 is rated 5.0 out of 5 by 1.
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Synonym: Ac-Tyr-Val-Ala-Asp-AFC; Caspase-1 substrate (fluorogenic), Caspase-4 substrate (fluorogenic)
Application: A fluorogenic substrate for caspase-1 and caspase-4
CAS Number: 219137-85-6
Purity: ≥97%
Molecular Weight: 719.67
Molecular Formula: C33H36F3N5O10
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ac-YVAD-AFC is a fluorogenic substrate for caspase-1 and caspase-4.


References

1. Marcelli, M., et al. 1998. Cancer Res. 58: 76-83. PMID: 9426061

Appearance :
Powder
Physical State :
Solid
Sequence :
Ac-Tyr-Val-Ala-Asp-AFC (AFC=7-Amino-4-trifluoromethylcoumarin)
Solubility :
Soluble in DMSO.
Storage :
Desiccate at -20° C
Boiling Point :
1084.64° C at 760 mmHg (Predicted)
Density :
1.42 g/cm3 (Predicted)
Refractive Index :
n20D 1.59 (Predicted)
Fluoresence :
λex 400 nm, λem 505 nm
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16760708
MDL Number :
MFCD01318881
SMILES :
C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)NC1=CC2=C(C=C1)C(=CC(=O)O2)C(F)(F)F)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC3=CC=C(C=C3)O)NC(=O)C

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Marks N; et al Marks N; et al. (PubMed ID: 9590441) determined that Ac-YVAD-AFC (a preferred substrate for caspase-1) did not increase the activity of caspase-3 in rat cerebellar granule cells exposed to apoptotic conditions. -SCBT Publication Review
Date published: 2015-02-15
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