Ac-VEID-pNA, Colorimetric SubstrateA substrate for caspase-6

Ac-VEID-pNA, Colorimetric Substrate (CAS 189684-54-6)

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Synonym: Ac-Val-Glu-Ile-Asp-PNA
Application: A substrate for caspase-6
CAS Number: 189684-54-6
Purity: ≥95%
Molecular Weight: 636.65
Molecular Formula: C28H40N6O11
* Refer to Certificate of Analysis for lot specific data (including water content).

Ac-VEID-pNA, Colorimetric Substrate is a colorimetric substrate for caspase-6 (Km=30μM; Kcat/Km=168’000 M-1sec-1) and related cysteine proteases. The sequence is based on the lamin A site of cleavage. Cleavage of the substrate by a caspase results in the release of pNA, which can be detected by its absorbance at 405nm (ε=10,500 M-1cm-1).


References

1. Srinivasula, S.M., et al. 1996. J. Biol. Chem. 271: 27099-27106. PMID: 8900201
2. Talanian, R.V., et al. 1997. J. Biol. Chem. 272: 9677-9682. PMID: 9092497
3. Thornberry, N.A., et al. 1997. J. Biol. Chem. 272: 17907-17911. PMID: 9218414

Usage :
Store stock solution in water at -20°C.
Appearance :
Lyophilized
Physical State :
Solid
Sequence :
N-acetyl-Val-Glu-Ile-Asp-pNA (p-nitroanilide)
Solubility :
Soluble in water, and DMSO (2 mM).
Storage :
Store at -20° C
Boiling Point :
1086.6 ± 65.0° C at 760 mmHg
Density :
1.3 ±0.1g/cm3
Refractive Index :
n20D 1.57
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
44135307
SMILES :
CCC(C)C(C(=O)NC(CC(=O)O)C(=O)NC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)C(CCC(=O)O)NC(=O)C(C(C)C)NC(=O)C

Download SDS (MSDS)

Certificate of Analysis

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Ac-VEID-pNA, Colorimetric Substrate  Product Citations

See how others have used Ac-VEID-pNA, Colorimetric Substrate. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 30795621  Nováková, J.|Talacko, P.|Novák, P.|Vališ, K.| et al. 2019. Cells. 8:

Citations 1 to 1 of 1 total
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