Ac-VEID-AFCA fluorogenic substrate for caspase-6

Ac-VEID-AFC

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Synonym: Ac-Val-Glu-Ile-Asp-AFC
Application: A fluorogenic substrate for caspase-6
Molecular Weight: 727.68
Molecular Formula: C32H40F3N5O11
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ac-VEID-AFC is a fluorogenic substrate for caspase-6 (Km=30μM; Kcat/Km=168000 M-1sec-1) and related cysteine proteases. The sequence is based on the lamin A site of cleavage.


References

1. Srinivasula, S.M., et al. 1996. J. Biol. Chem. 271: 27099-27106. PMID: 8900201
2. Talanian, R.V., et al. 1997. J. Biol. Chem. 272: 9677-9682. PMID: 9092497
3. Thornberry, N.A., et al. 1997. J. Biol. Chem. 272: 17907-17911. PMID: 9218414

Physical State :
Solid
Solubility :
DMSO or dimethyl formamide
Storage :
Store at -20° C
Fluoresence :
λex 400 nm λem 505 nm
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
44135099
SMILES :
CCC(C)C(C(=O)NC(CC(=O)O)C(=O)NC1=CC2=C(C=C1)C(=CC(=O)O2)C(F)(F)F)NC(=O)C(CCC(=O)O)NC(=O)C(C(C)C)NC(=O)C

Download SDS (MSDS)

Certificate of Analysis

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