Ac-VAD-AFC MF: C24H27F3N4O8
MW: 556.5
A fluorogenic substrate for caspase-1.

Ac-VAD-AFC

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Alternate Names: Caspase Substrate I; N-Acetyl-Val-Ala-Asp-7-amido-4-trifluoromethylcoumarin
Application: Ac-VAD-AFC is a fluorogenic substrate for caspase-1
Purity: ≥98%
Molecular Weight: 556.5
Molecular Formula: C24H27F3N4O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ac-VAD-AFC is a fluorogenic caspase-1 substrate. It may also be employed as a caspase-3, caspase-4, or caspase-7 substrate. The reaction can be observed by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore.

Appearance :
Lyophilized
Physical State :
Solid
Sequence :
Ac-Val-Ala-Asp-AFC (AFC=7-Amino-4-trifluoromethylcoumarin)
Solubility :
Soluble in DMSO (5 mg/ml), and DMF.
Storage :
Store at -20° C
Boiling Point :
881.23° C at 760 mmHg (Predicted)
Density :
1.42 g/cm3 (Predicted)
Refractive Index :
n20D 1.56 (Predicted)
Fluoresence :
λex 400 nm, λem 505 nm
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD02259218
SMILES :
C[[email protected]@H](C(=O)N[[email protected]@H](CC(=O)O)C(=O)NC1=CC2=C(C=C1)C(=CC(=O)O2)C(F)(F)F)NC(=O)[[email protected]](C(C)C)NC(=O)C

Download SDS (MSDS)

Certificate of Analysis

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Ac-VAD-AFC  Product Citations

See how others have used Ac-VAD-AFC. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 33748630  Singh, N.|Barnych, B.|Wagner, KM.|Wan, D.|Morisseau, C.|Hammock, BD.| et al. 2021. ACS Omega. 6: 7165-7174.

Citations 1 to 1 of 1 total
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