ABT-888CAS: 912445-05-7
MF: C13H16N4O•2HCl
MW: 317.22
A potent PARP-1 and PARP-2 inhibitor.

ABT-888 (CAS 912445-05-7)

ABT-888 | CAS 912445-05-7 is rated 5.0 out of 5 by 1.
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Synonym: Veliparib; 2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide dihydrochloride
Application: A potent PARP-1 and PARP-2 inhibitor
CAS Number: 912445-05-7
Purity: ≥97%
Molecular Weight: 317.22
Molecular Formula: C13H16N4O•2HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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ABT-888 has been shown to inhibit PARP-1 and PARP-2, enzymes which catalyze the addition of ADP-ribose units to proteins that mediate DNA repair pathways. PARP is also important in initiating apoptosis, and thus inhibition of these enzymes reduces the rate of apoptosis in DNA-damaged cells.


References

1. Albert, J.M. et al. 2007. Clin. Cancer Res. 13(10): 3033-3042. PMID: 17505006

2. Liu, S.K. et al. 2008. Radiother Oncol. 88(2): 258-268. PMID: 18456354

3. Palma, J.P. et al. 2009. Clin. Cancer Res. 15(23): 7277-7290. PMID: 19934293

4. Horton, T.M. et al. 2009. Mol. Cancer Ther. 8(8): 2232-2242. PMID: 19671751

5. Muscal, J.A. et al. 2010. Cancer Chemother. Pharmacol. 65(3): 419-425. PMID: 19526240

Usage :
Stable for up to 1 year after receipt when stored at -20°C. Stock solutions should be aliquoted and stored at -20°C for up to 1 month.
Physical State :
Solid
Solubility :
Soluble in organic solvents purged with an inert gas: DMSO (15 mg/ml), ethanol (0.1 mg/ml), DMF (0.25 mg/ml), and in PBS, pH 7.2 (10 mg/ml).
Storage :
Store at -20° C
Refractive Index :
n20D 1.65 (Predicted)
IC50 :
PARP activity : EC5050 = 2 nM (C41 cells)
Ki Data :
PARP-2: Ki= 5 nM (human); PARP-1: Ki= 5 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
45480520
MDL Number :
MFCD16661206
SMILES :
C[[email protected]@]1(CCCN1)C2=NC3=C(C=CC=C3N2)C(=O)N.Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

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ABT-888  Product Citations

See how others have used ABT-888. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 11 total

PMID: # 30250272  Whelan, DR. et al. 2018. Nat Commun. 9: 3882.

PMID: # 27197561  Ozden, O. et al. 2016. Sci Rep. 6: 26273.

PMID: # 27466483  2016. Anticancer research. 36: 3821-6.

PMID: # 26719576  Alagpulinsa, DA. et al. 2016. Mol. Cancer Ther. 15: 241-50.

PMID: # 26317470  Patel, A. et al. 2015. Cell. 162: 1066-77.

PMID: # 25366693  Lemaître, C. et al. 2014. Genes Dev. 28: 2450-63.

PMID: # 24994771  Cho, HY. et al. 2014. Mol. Cancer Ther. 13: 2004-17.

PMID: # 20610628  Efimova, EV. et al. 2010. Cancer Res. -.

PMID: # 19823047  Yang, SX. et al. 2009. Cancer Biol. Ther. 8: 2004-2009.

PMID: # 19174557  Clarke, MJ. et al. 2009. Mol. Cancer Ther. 8: 407-414.

Citations 1 to 10 of 11 total

What is the solubility in organic solvents, such as DMSO?

Asked by: SCM4
This chemical, ABT-888 (CAS 912445-05-7), is soluble in organic solvents purged with an inert gas: DMSO (15 mg/ml), ethanol (0.1 mg/ml), DMF (0.25 mg/ml), and in PBS, pH 7.2 (10 mg/ml).
Answered by: Chemical Support 1
Date published: 2017-03-24
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Rated 5 out of 5 by from Kron et al Kron et al. (PubMed ID 20610628) used ABT-888, a PARP inhibitor, to prevent double-strand break repair in breast cancer cells after treatment with ionizing radiation. -SCBT Publication Review
Date published: 2015-04-12
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