ABS 205 is an orally active valproic acid derivative that exhibits neuroprotective and teratogenic activity. Research studies have shown that ABS 205 upregulates neural cell adhesion molecule (NCAM) expression, activates PPARβ (IC50 = 0.6 mM) and increases Hoxa1 expression in rat embryos. ABS 205 also exhibits antiproliferative properties as shown by an ability to induce G1 cell cycle arrest in C6 glioma cells (IC50 ~ 2 mM).
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