ABS 205A valproic acid derivative

ABS 205 (CAS 24102-11-2)

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Synonym: 4-yn-VPA
Application: A valproic acid derivative
CAS Number: 24102-11-2
Molecular Weight: 140.18
Molecular Formula: C8H12O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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ABS 205 is an orally active valproic acid derivative that exhibits neuroprotective and teratogenic activity. Research studies have shown that ABS 205 upregulates neural cell adhesion molecule (NCAM) expression, activates PPARβ (IC50 = 0.6 mM) and increases Hoxa1 expression in rat embryos. ABS 205 also exhibits antiproliferative properties as shown by an ability to induce G1 cell cycle arrest in C6 glioma cells (IC50 ~ 2 mM).


1. Lampen, Alfonso., et al., 2005. Modulation of peroxisome proliferator-activated receptor delta activity affects neural cell adhesion molecule and polysialyltransferase ST8SiaIV induction by teratogenic valproic acid analogs in F9 cell differentiation. Molecular pharmacology. 68(1): 193-203. PMID: 15829700
2. Stodgell, Christopher J., et al., . Induction of the homeotic gene Hoxa1 through valproic acid's teratogenic mechanism of action. Neurotoxicology and teratology. 28(5): 617-24. PMID: 16989981
3. Bacon, C L., et al., 1998. Cell proliferation, migration and CAM-dependent neurite outgrowth as developmental in vitro endpoints for screening teratogenic potential: Application to valproic acid and related analogues of varying potency. Toxicology in vitro : an international journal published in association with BIBRA. 12(2): 101-9. PMID: 20654391

Physical State :
Solubility :
Soluble in DMSO (100 mM), and ethanol (100 mM).
Storage :
Store at 4° C
Melting Point :
50.98° C (Predicted)
Boiling Point :
234.80° C at 760 mmHg (Predicted)
Density :
1.01 g/mL (Predicted)
Refractive Index :
n20D 1.46 (Predicted)
IC50 :
Activates PPARδ: IC50 = 0.6 mM; G1 cell cycle arrest: IC50 = ~2 mM (C6 glioma cells)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :

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Certificate of Analysis

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