AAL-993A cell permeable inhibitor of VEGFR-1 (Flt-1), VEGFR-2 (Flk-1) and VEGFR-3 (Flt-4)

AAL-993 (CAS 269390-77-4)

AAL-993 | CAS 269390-77-4 is rated 5.0 out of 5 by 1.
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Synonym: VEGFR Tyrosine Kinase Inhibitor VI; 2-((4-Pyridyl)methyl)amino-N-(3-(trifluoromethyl)phenyl)benzamide
Application: A cell permeable inhibitor of VEGFR-1 (Flt-1), VEGFR-2 (Flk-1) and VEGFR-3 (Flt-4)
CAS Number: 269390-77-4
Purity: ≥98%
Molecular Weight: 371.36
Molecular Formula: C20H16N3OF3
* Refer to Certificate of Analysis for lot specific data (including water content).
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AAL-993 is a highly potent inhibitor of Flt-1 (VEGFR-1), Flk-1 (VEGFR-2) and Flt-4 (VEGFR-3) (IC50=130nM, IC50=23nM and IC50=18nM respectively). At higher concentrations it inhibits PDGFR-β (640nM), c-Kit (236nM) and c-Fms-CSF-1R (CSF-1R) (380nM). AAL-993 shows no activity towards other kinases such as EGFR, FGFR-1, CDK-1, Tie-2, c-Met, IGF-1R, c-Src and c-Abl. An X-ray crystal structure of AAL-993 complexed with the catalytic domain of diphosphorylated VEGFR-2 indicates that this molecule binds to an inactive conformation of the protein.

Physical State :
Solid
Solubility :
Soluble in ethanol (15 mg/ml), and DMSO (>25 mg/ml).
Storage :
Store at room temperature
Melting Point :
214.83° C
Boiling Point :
~441.26° C at 760 mmHg (Predicted)
Density :
1.35 g/cm3
Refractive Index :
n20D 1.63
IC50 :
VEGFR-1: IC50 = 130 nM; VEGFR-2: IC50 = 23 nM; VEGFR-3: IC50 = 18 nM; PDGFR-β: IC50 = 640 nM; c-Kit : IC50 = 236 nM; CSF-1R: IC50 = 380 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
6398883
SMILES :
C1=CC=C(C(=C1)C(=O)NC2=CC=CC(=C2)C(F)(F)F)NCC3=CC=NC=C3

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Certificate of Analysis

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Rated 5 out of 5 by from AAL AAL-993 was reported in many articles to prevent primary tumor growth in mice and inhibit VEGFR1-3. -SCBT Publication Review
Date published: 2015-03-14
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