Molecular structure of A77 1726, CAS Number: 163451-81-8
A77 1726 (CAS 163451-81-8)
See product citations (14)
Alternate Names:
A 1726, A77-1726, A771726, Flucyamide, HMR 1726, N-(4-Trifluoromethylphenyl)-2-cyano-3-hydroxycrotoamide, SU 20
Application:
A77 1726 is an active metabolite of leflunomide that inhibits Cox-2
CAS Number:
163451-81-8
Purity:
≥98%
Molecular Weight:
270.21
Molecular Formula:
C12H9F3N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A77 1726, also known as teriflunomide, is the active metabolite of leflunomide (sc-202209). This compound has demonstrated antiinflammatory, antiproliferative, and immunosuppressive effects. A77 1726 may act to inhibit the proliferation of multiple mammalian cell lines in vitro, has demonstrated inhibition of Cox-2, dendritic cell function, DHODH (dihydroorotate dehydrogenase), and blocks TNF-dependent nuclear factor-kappa B activation and gene expression. DHODH is an enzyme involved in the de novo synthesis of pyrimidine nucleotides, and its inhibition is thought to result in the antiproliferative effects on rapidly dividing cells, such as T-cells, observed by this compound.
A77 1726 (CAS 163451-81-8) References
- A771726, the active metabolite of leflunomide, directly inhibits the activity of cyclo-oxygenase-2 in vitro and in vivo in a substrate-sensitive manner. | Hamilton, LC., et al. 1999. Br J Pharmacol. 127: 1589-96. PMID: 10455314
- The active metabolite of leflunomide, A77 1726, interferes with dendritic cell function. | Kirsch, BM., et al. 2005. Arthritis Res Ther. 7: R694-703. PMID: 15899055
- Pharmacokinetics and pharmacodynamics of A77 1726 and leflunomide in domestic cats. | Mehl, ML., et al. 2012. J Vet Pharmacol Ther. 35: 139-46. PMID: 21615755
- Postinfection A77-1726 treatment improves cardiopulmonary function in H1N1 influenza-infected mice. | Aeffner, F., et al. 2012. Am J Respir Cell Mol Biol. 47: 543-51. PMID: 22679275
- A77 1726, the active metabolite of leflunomide, attenuates lupus nephritis by promoting the development of regulatory T cells and inhibiting IL-17-producing double negative T cells. | Qiao, G., et al. 2015. Clin Immunol. 157: 166-74. PMID: 25638413
- A77 1726, the active metabolite of the anti-rheumatoid arthritis drug leflunomide, inhibits influenza A virus replication in vitro and in vivo by inhibiting the activity of Janus kinases. | Wang, J., et al. 2020. FASEB J. 34: 10132-10145. PMID: 32598086
- Inhibition of porcine epidemic diarrhea virus (PEDV) replication by A77 1726 through targeting JAK and Src tyrosine kinases. | Li, X., et al. 2020. Virology. 551: 75-83. PMID: 32829915
- Therapeutic response to leflunomide in combo therapy and monotherapy is associated to serum teriflunomide (A77 1726) levels. | Fajardo-Robledo, NS., et al. 2022. Sci Rep. 12: 1877. PMID: 35115601
- Inhibition of protein tyrosine phosphorylation in T cells by a novel immunosuppressive agent, leflunomide. | Xu, X., et al. 1995. J Biol Chem. 270: 12398-403. PMID: 7759480
- Inhibition of the epidermal growth factor receptor tyrosine kinase activity by leflunomide. | Mattar, T., et al. 1993. FEBS Lett. 334: 161-4. PMID: 8224241
- The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase. | Davis, JP., et al. 1996. Biochemistry. 35: 1270-3. PMID: 8573583
- Two activities of the immunosuppressive metabolite of leflunomide, A77 1726. Inhibition of pyrimidine nucleotide synthesis and protein tyrosine phosphorylation. | Xu, X., et al. 1996. Biochem Pharmacol. 52: 527-34. PMID: 8759024
- The immunosuppressive metabolite of leflunomide, A77 1726, affects murine T cells through two biochemical mechanisms. | Elder, RT., et al. 1997. J Immunol. 159: 22-7. PMID: 9200434
- In vivo mechanism by which leflunomide controls lymphoproliferative and autoimmune disease in MRL/MpJ-lpr/lpr mice. | Xu, X., et al. 1997. J Immunol. 159: 167-74. PMID: 9200452
- Immunosuppressive leflunomide metabolite (A77 1726) blocks TNF-dependent nuclear factor-kappa B activation and gene expression. | Manna, SK. and Aggarwal, BB. 1999. J Immunol. 162: 2095-102. PMID: 9973483
Inhibitor of:
β-defensin 39, BTN3A1, C1orf112, Cox, Cox-2, CPS II, CTP Synthase (CTPS), DHODH, EG243302, HMG-2L1, ICF45, IgG, LOC643623, MHC, OTTMUSG00000011291, Prdx6-rs2, SGS3, T-cell receptor Vδ 1, Trx-2, TSARG2, and WC1.Activator of:
DHODH, IgM, IL-17RA, IMPDH1, IRAK-M, and SPPL2b.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
A77 1726, 10 mg | sc-207235 | 10 mg | $80.00 |