A66CAS: 1166227-08-2
MF: C17H23N5O2S2
MW: 393.5
An inhibitor for oncogenic forms of p110.

A66 (CAS 1166227-08-2)

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Application: An inhibitor for oncogenic forms of p110
CAS Number: 1166227-08-2
Purity: ≥98%
Molecular Weight: 393.5
Molecular Formula: C17H23N5O2S2
* Refer to Certificate of Analysis for lot specific data (including water content).

A66 inhibits the oncogenic forms of p110α such as E545K H1047R with IC50 of 30 nM and 43 nM, respectively. A66 displays >100-fold selectivity for p110α over other class-I PI3K isoforms. Among the class-II PI3Ks, class-III PI3Ks, and PI4Ks, A66 only exhibits limited cross-reactivity with the class-II PI3K PI3K-C2β and the PI4Kβ isoform of PI4K with IC50 of 462 nM and 236 nM, respectively. A66 exhibits no inhibitory activity against other lipid kinases or the related kinases DNA-PK and mTOR. A66 treatment at 0.7 μM induces a 75-80% reduction in focus formation by the highly transforming p85α iSH2 mutants KS459delN, DKRMN-S560del, and K379E, and reduces the phosphorylation of Akt on T308 by all p85 mutants.

Physical State :
Solid
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
42636535
SMILES :
CC1=C(SC(=N1)NC(=O)N2CCC[[email protected]]2C(=O)N)C3=CSC(=N3)C(C)(C)C

Download SDS (MSDS)

Certificate of Analysis

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