A23187A highly selective Ca2+ ionophore

A23187 (CAS 52665-69-7)

A23187 | CAS 52665-69-7 is rated 5.0 out of 5 by 1.
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Synonym: Calimycin;Antibiotic A-23187
Application: A highly selective Ca2+ ionophore
CAS Number: 52665-69-7
Purity: ≥97%
Molecular Weight: 523.62
Molecular Formula: C29H37N3O6
* Refer to Certificate of Analysis for lot specific data (including water content).
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A23187 is an ionophore, highly selective for Ca2+, that allows for divalent cations to move across the membranes which are usually impermeable to them. The compound was originally isolated from Streptomyces chartreusensis for use as an antibiotic but has been shown to have weak in vitro antimicrobial activity against fungi and gram positive bacteria. Because of its ability to increase intracellular calcium levels of intact cells, it is used in studies of intracellular Ca2+ mediated events. A23187 has been observed to induce cell activation, differentiation or proliferation. In vitro experimentation has shown A23187 to boost ROS generation and platelet fragmentation.


References

1. Gietzen K., et al. 1982. Biochem. J. 207: 541-548. PMID: 6299272
2. Li, W.C., et al. 1995. Exp Eyes Res. 61:91-98. PMID: 7556474
3. Wong, D.T., et al. 1973. Arch Biochem Biophys. 156: 578-585. PMID: 4268878
4. Reed, P.W., et al. 1972. J Biol Chem. 247: 6970-6977. PMID: 426361
5. Przygodzki, T., et al. 2005. Biochim Biophys Acta, 1740: 481-488. PMID: 15949718
6. Nardi, M.A., et al. 2007. Blood. 110: 1989-1996. PMID: 17545506
7. Kajitani, N., et al. 2007. Biosci Biotechnol Bichem. 71: 2701-2711. PMID: 17986779

Physical State :
Solid
Derived From :
Streptomyces chartreusis
Solubility :
Soluble in water (Partly miscible), DMSO (1 mg/ml), and DMF (10 mg/ml).
Storage :
Store at -20° C
Boiling Point :
~710.33° C at 760 mmHg (Predicted)
Density :
~1.29 g/cm3 (Predicted)
Refractive Index :
n20D 1.61 (Predicted)
pK Values :
pKa: 0.33, pKb: 8.27
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
DM4676000
PubChem CID :
11957499
Merck Index :
14: 1639
MDL Number :
MFCD00151202
EC Number :
258-084-1
Beilstein Registry :
1096801
SMILES :
C[C@@H]1CC[C@]2([C@@H](C[C@H]([C@H](O2)[C@H](C)C(=O)C3=CC=CN3)C)C)O[C@@H]1CC4=NC5=C(O4)C=CC(=C5C(=O)O)NC

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A23187  Product Citations

See how others have used A23187. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 13 total

PMID: # 26862528  Kawata, J. et al. 2016. Cell J. 17: 692-700.

PMID: # 25996296  Montagne, R. et al. 2015. Cell Death Dis. 6: e1769.

PMID: # 25356863  Yoon, S. et al. 2014. Cell Death Dis. 5: e1494.

PMID: # 16890768  Wu, X. et al. 2006. J. Allergy Clin. Immunol. 118: 428-433.

PMID: # 15845771  Kanemori, Y. et al. 2005. Proc. Natl. Acad. Sci. USA. 102: 6279-6284.

PMID: # 15322221  Kyttaris, VC. et al. 2004. J. Immunol. 173: 3557-3563.

PMID: # 12574323  McCurdy, JD. et al. 2003. J. Immunol. 170: 1625-1629.

PMID: # 14551684  Hattori, Y. et al. 2003. Diabetologia. 46: 1543-1549.

PMID: # 12031651  Baj-Krzyworzeka, M. et al. 2002. Exp. Hematol. 30: 450-459.

PMID: # 11078876  Burgun, C. et al. 2000. FEBS Lett. 484: 189-193.

Citations 1 to 10 of 13 total
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Rated 5 out of 5 by from Wu Wu, et. al. (PubMed ID 16890768) used A23187 to challenge cells cultured from nasal tissue; post challenge (1 g/ml for 30 minutes at 37 degrees Celsius), the level histamines released into the supernatant were then measured. -SCBT Publication Review
Date published: 2015-04-13
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