A 987306 CAS: 1082954-71-9
MF: C18H25N5O
MW: 327.42
A potent and selective histamine H4 receptor antagonist.

A 987306 (CAS 1082954-71-9)

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Application: A potent and selective histamine H4 receptor antagonist
CAS Number: 1082954-71-9
Molecular Weight: 327.42
Molecular Formula: C18H25N5O
* Refer to Certificate of Analysis for lot specific data (including water content).
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A 987306 is a potent histamine H4 receptor antagonist (pKi values are 8.24 and 8.47 in human and rat H4 receptors respectively). This compound displays 162-fold, 620-fold, and > 1600-fold selectivity over human H3, H1 and H2 receptors.


References

Liu et al (2008) cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia. J.Med.Chem. 51 7094. Leurs et al (2009) Molecular and biochemical pharmacology of the histamine H4 receptor. Br.J.Pharmacol. 157 14.

Physical State :
Solid
Solubility :
DMSO (100 mM) and ethanol (100mM)
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
44538833
SMILES :
C1CC[[email protected]@H]2[[email protected]](C1)C3=C(O2)CCC4=C3N=C(N=C4N5CCNCC5)N

Download SDS (MSDS)

Certificate of Analysis

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