A 943931 dihydrochlorideA potent and selective H4 receptor antagonist

A 943931 dihydrochloride (CAS 1227675-50-4)

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Application: A potent and selective H4 receptor antagonist
CAS Number: 1227675-50-4
Molecular Weight: 368.31
Molecular Formula: C17H21N52HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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A 943931 dihydrochloride is a potent and selective histamine H4 receptor antagonist (pKi values are 7.15 and 8.12 at human and rat receptors respectively). This compound blocks inflammation in murine models and displays efficacy in inflammatory pain and neuropathic pain models.


References

Cowart et al (2008) Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class of histamine H4 receptor antagonists with improved druglikeness and in vivo efficacy in pain and inflammation models. J.Med.Chem. 51 6547. Leurs et al (2009) Molecular and biochemical pharmacology of the histamine H4 receptor. Br.J.Pharmacol. 157 14.

Physical State :
Solid
Solubility :
water (100mM) and DMSO (100mM)
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
SMILES :
c1ccc-2c(c1)CCCc3c2nc(nc3N4CC[C@H](C4)N)N.Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

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