A 922500A diacyl glycerolacyltransferase 1 inhibitor

A 922500 (CAS 959122-11-3)

A 922500 | CAS 959122-11-3 is rated 5.0 out of 5 by 1.
  • y_2019, m_11, d_14, h_22
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.2
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_203793, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 96ms
  • REVIEWS, PRODUCT
5
1
4
0
3
0
2
0
1
0
Synonym: DGAT-1Inhibitor 4a
Application: A diacyl glycerolacyltransferase 1 inhibitor
CAS Number: 959122-11-3
Purity: ≥96%
Molecular Weight: 428.48
Molecular Formula: C26H24N2O4
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

A 922500 is a diacyl glycerolacyltransferase 1 (DGAT-1) inhibitor (IC50 values are 7 and 24 nM at human and mouse DGAT-1 respectively) that is devoid of activity at DGAT-2, ACAT1 or ACAT2.


References

Zhao et al (2008) Validation of diacyl glycerolacyltransferase I as a novel target of obesity and dyslipidemia using a potent and selective small molecule inhibitor. J.Med.Chem. 51 380. King et al (2009) Diacylglycerol acyltransferase 1 inhibition lowers serum triglycerides in the zucker fatty rat and the hyperlipidemic hamster. J.Pharmacol.Exp.Ther. 330 526.

Physical State :
Solid
Solubility :
Soluble in DMSO (50 mM), ethanol (~0.2 mg/ml), DMF (~20 mg/ml), DMSO:PBS (1:10 pH 7.2) (~0.1 mg/ml), and water (<1 mg/ml) at 25° C.
Storage :
Desiccate at -20° C
Boiling Point :
576.11° C at 760 mmHg (Predicted)
Density :
1.32 g/cm3 (Predicted)
Refractive Index :
n20D 1.68 (Predicted)
IC50 :
DGAT-1: IC50 = 7 nM (human); DGAT-1: IC50 = 24 nM (mouse); DGAT-2: IC50 = 53 µM; acyl coenzyme A cholesterol acyltransferase-1: IC50 = 296 µM; acyl coenzyme A cholesterol acyltransferase-1: IC50 = 296 µM
pK Values :
pKa: 4.32 (Predicted), pKb: 0.3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
GU8624000
PubChem CID :
24768261
MDL Number :
MFCD12828780
SMILES :
O=C(Nc1ccc(cc1)c1ccc(cc1)C(=O)[C@@H]1CCC[C@H]1C(=O)O)Nc1ccccc1

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

A 922500  Product Citations

See how others have used A 922500. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 22365411  Kim, Y. et al. 2012. Eur J Med Chem. 50: 311-8.

Citations 1 to 1 of 1 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 92ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Tsuda et al Tsuda et al. (PubMed ID 25405858) found that A- 922500 attenuated obesity and insulin resistance without causing skin problems in mice via DGAT1 inhibition. -SCBT Publication Review
Date published: 2015-04-29
  • y_2019, m_11, d_14, h_22
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.2
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_203793, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 49ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.