A 841720CAS: 869802-58-4
MF: C17H21N5OS
MW: 343.45
A potent & non-competitive mGluR-1 antagonist.

A 841720 (CAS 869802-58-4)

A 841720 | CAS 869802-58-4 is rated 5.0 out of 5 by 1.
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Synonym: 9-(Dimethylamino)-3-(hexahydro-1H-azepin-1-yl)pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(3H)-one
Application: A potent & non-competitive mGluR-1 antagonist
CAS Number: 869802-58-4
Purity: ≥98%
Molecular Weight: 343.45
Molecular Formula: C17H21N5OS
* Refer to Certificate of Analysis for lot specific data (including water content).
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A 841720 is a potent, non-competitive mGluR-1 antagonist that displays 34-fold selectivity over mGluR-5 (IC50 values are 10 and 342 nM respectively). A 841720 displays no significant activity at a range of other GPCRs, ion channels and transporters. This compound also exhibits analgesic effects, decreases mechanical allodynia in models of neuropathic pain, and impairs cognitive function.


References

Zheng et al (2005) Structure-activity relationship of triazafluorenone derivatives as potent and selective mGluR1 antagonists. J.Med.Chem. 48 7374. El-Kouhen et al (2006) Blockade of mGluR1 receptor results in analgesia and disruption of motor and cognitive performances: effects of A-841720, a novel non-competitive mGluR1 receptor antagonist. Br.J.Pharmacol. 149 761. More et al (2007) Comparison of the mGluR1 antagonist A-841720 in rats models of pain and cognition. Behav.Pharmacol. 18 273.

Physical State :
Solid
Solubility :
Soluble to 50 mM in DMSO and to 50 mM in Ethanol
Storage :
Store at room temperature
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
11559235
SMILES :
CN(C)C1=C2C3=C(C(=O)N(C=N3)N4CCCCCC4)SC2=NC=C1

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Zhu et al Zhu et al. (PubMed ID 18054908) found that the mGlu1 receptor antagonists A-841720 reduced spontaneous post-operative pain behavior in rats, revealing that mGlu1 receptor activation plays a significant role in nociceptive transmission. -SCBT Publication Review
Date published: 2015-07-03
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