A 77636 hydrochlorideA selective dopamine D1-like receptor agonist

A 77636 hydrochloride (CAS 145307-34-2)

A 77636 hydrochloride | CAS 145307-34-2 is rated 5.0 out of 5 by 1.
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Application: A selective dopamine D1-like receptor agonist
CAS Number: 145307-34-2
Purity: >98%
Molecular Weight: 365.9
Molecular Formula: C20H27NO3.HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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A 77636 hydrochloride is a selective and potent dopamine D1-like agonist stimulating the release of adenylate cyclase. It has been reported that upon binding to D1DR (dopamine D1 receptors), A 77636 hydrochloride displays 85% of the intrinsic activity that dopamine provides. Some studies show that A 77636 hydrochloride also increases the release of cortical acetylcholine. A 77636 hydrochloride is an activator of D1DR.


References

1. Kebabian, J.W., et al. 1992. Eur. J. Pharmacol. 229: 203-209. PMID: 1362704
2. Acquas, E., et al. 1994. Eur. J. Pharmacol. 260: 85-87. PMID: 7957630
3. Lewis, M.M., et al. 1998. J. Pharmacol. Exp. Ther. 286: 345-353. PMID: 9655879

Physical State :
Solid
Solubility :
Soluble in water (100 mM), ethanol (100 mM), and DMSO (100 mM).
Storage :
Store at 4° C
Melting Point :
220° C
Boiling Point :
515.3° C at 760 mmHg (Predicted)
Refractive Index :
n20D ~1.64 (Predicted)
Optical Activity :
α20/D -76°, c = 0.93 in methanol
IC50 :
BJ: EC5050 = 10.31 µM (human); Plasmodium falciparum: IC50 = 2.0 µM; UBC13: IC50 = >20 µM (human); ATP-dependent molecular chaperone HSP82: EC5050 = 3.36 µM (Candida albicans (strain WO-1) (Yeast))
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
DJ2540500
PubChem CID :
9951033
MDL Number :
MFCD03107804
SMILES :
C1C2CC3CC1CC(C2)(C3)C4CC5=C(C=CC(=C5O)O)C(O4)CN.Cl

Download SDS (MSDS)

Certificate of Analysis

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A 77636 hydrochloride  Product Citations

See how others have used A 77636 hydrochloride. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 10891867  Mehta, A. et al. 2000. Synapse. 37: 298-307.

PMID: # 9425179  Cepeda, C. et al. 1998. J. Neurophysiol. 79: 82-94.

PMID: # 8100194  Asin, KE. et al. 1993. Eur. J. Pharmacol. 235: 167-168.

Citations 1 to 3 of 3 total
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Rated 5 out of 5 by from Mehta Mehta, et al. (PubMed ID 10891867) found that A77636, a selective D1 agonist, induced involuntary repetitive movements of the mouse and face of rats when it was injected into the subthalamic nucleus (part of the basal ganglia system in the brain). -SCBT Publication Review
Date published: 2015-02-03
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