A-71623 CAS: 130408-77-4
MF: C44H56N8O9
MW: 840.97
A potent CCK agonist with 1200-fold selectivity over the CCK2 receptor.

A-71623 (CAS 130408-77-4)

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Application: A-71623 is a potent CCK agonist with 1200-fold selectivity over the CCK2 receptor
CAS Number: 130408-77-4
Molecular Weight: 840.97
Molecular Formula: C44H56N8O9
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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A-71623 is a tetrapeptide that acts as a robust and selective CCK (cholecystokinin) receptor agonist. CCK is a neuroendocrine peptide described to play an important role in cell growth, cell proliferation, and other biological functions. Studies report that in comparison to other cholecystokinin agonists A-71623 does not have a tyrosine residue in which sulfation is necessary for strong cholecystokinin agonist activity in larger peptides. The compound has been used in animal studies to suppress appetite.


References

1. Lin, C.W., et al. 1991. Mol. Pharmacol. 39: 346-351. PMID: 1706470
2. Asin, K.E., et al. 1992. Pharmacol. Biochem. Behav. 42: 699-704. PMID: 1513850
3. Cannon, J.B., et al. 1996. J Drug Target. 4: 69-78. PMID: 8894966
4. Carrillo, J., et al. 2009. Anticancer Drugs. 20: 527-533. PMID: 19407653

Physical State :
Solid
Solubility :
Soluble in 30% acetonitrile / 0.2% NH4OH (0.67 mg/ml ).
Storage :
Desiccate at -20° C
Boiling Point :
1126.59° C at 760 mmHg (Predicted)
Density :
1.29 g/cm3 (Predicted)
Refractive Index :
n20D 1.62 (Predicted)
IC50 :
CCK-AR: IC50 = 3.7 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
121964
MDL Number :
MFCD00897724
SMILES :
CC1=CC=CC=C1NC(=O)NCCCC[[email protected]@H](C(=O)N[[email protected]@H](CC(=O)O)C(=O)N(C)[[email protected]@H](CC2=CC=CC=C2)C(=O)N)NC(=O)[[email protected]](CC3=CNC4=CC=CC=C43)NC(=O)OC(C)(C)C

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Certificate of Analysis

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A-71623 (CAS 130408-77-4) Product Citations

See how others have used A-71623 (CAS 130408-77-4). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 24825903  Desai, AJ. et al. 2014. J. Biol. Chem. 289: 18314-26.

Citations 1 to 1 of 1 total
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