Molecular structure of A-71623, CAS Number: 130408-77-4
A-71623 (CAS 130408-77-4)
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Application:
A-71623 is a potent CCK agonist with 1200-fold selectivity over the CCK2 receptor
CAS Number:
130408-77-4
Molecular Weight:
840.97
Molecular Formula:
C44H56N8O9
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
A-71623 is a tetrapeptide that acts as a robust and selective CCL28 (cholecystokinin 1; CCK1) receptor agonist. CCK is a neuroendocrine peptide described to play an important role in cell growth, cell proliferation, and other biological functions. Studies report that in comparison to other CCL28 agonists A-71623 does not have a tyrosine residue in which sulfation is necessary for strong CCL28 agonist activity in larger peptides. The compound has been used in animal studies to suppress appetite.
A-71623 (CAS 130408-77-4) References
- The design and synthesis of the high efficacy, non-peptide CCK1 receptor agonist PD170292. | Bernad, N., et al. 2000. Bioorg Med Chem Lett. 10: 1245-8. PMID: 10866391
- Inhibition by CCK of ascending contraction elicited by mucosal stimulation in the duodenum of the rat. | Giralt, M. and Vergara, P. 2000. Neurogastroenterol Motil. 12: 173-80. PMID: 10877605
- Differential effects of the CCKA receptor ligands PD-140,548 and A-71623 on latent inhibition in the rat. | Gracey, DJ., et al. 2002. Prog Neuropsychopharmacol Biol Psychiatry. 26: 497-504. PMID: 11999900
- A-71623, a selective CCK-A receptor agonist, suppresses food intake in the mouse, dog, and monkey. | Asin, KE., et al. 1992. Pharmacol Biochem Behav. 42: 699-704. PMID: 1513850
- Effects of selective CCK receptor agonists on food intake after central or peripheral administration in rats. | Asin, KE., et al. 1992. Brain Res. 571: 169-74. PMID: 1611492
- Both CCK-A and CCK-B/gastrin receptors mediate pepsinogen release in guinea pig gastric glands. | Lin, CW., et al. 1992. Am J Physiol. 262: G1113-20. PMID: 1616041
- Characterization of two novel cholecystokinin tetrapeptide (30-33) analogues, A-71623 and A-70874, that exhibit high potency and selectivity for cholecystokinin-A receptors. | Lin, CW., et al. 1991. Mol Pharmacol. 39: 346-51. PMID: 1706470
- Devazepide, a nonpeptide antagonist of CCK receptors, induces apoptosis and inhibits Ewing tumor growth. | Carrillo, J., et al. 2009. Anticancer Drugs. 20: 527-33. PMID: 19407653
- Gastrin-releasing peptide/neuromedin B receptor antagonists PD176252, PD168368, and related analogs are potent agonists of human formyl-peptide receptors. | Schepetkin, IA., et al. 2011. Mol Pharmacol. 79: 77-90. PMID: 20943772
- Stimulation of in vivo pancreatic growth in the rat is mediated specifically by way of cholecystokinin-A receptors. | Povoski, SP., et al. 1994. Gastroenterology. 107: 1135-46. PMID: 7523219
- Cholecystokinin blockade of emotional stress- and CRF-induced colonic motor alterations in rats: role of the amygdala. | Gué, M., et al. 1994. Brain Res. 658: 232-8. PMID: 7834346
- CCK-A receptor selective antagonists derived from the CCK-A receptor selective tetrapeptide agonist Boc-Trp-Lys(Tac)-Asp-MePhe-NH2 (A-71623). | Sugg, EE., et al. 1995. J Med Chem. 38: 207-11. PMID: 7837233
- Stimulation of growth of azaserine-induced putative preneoplastic lesions in rat pancreas is mediated specifically by way of cholecystokinin-A receptors. | Povoski, SP., et al. 1993. Cancer Res. 53: 3925-9. PMID: 8358719
- Alternate drug delivery routes for A-71623, a potent cholecystokinin-A receptor agonist tetrapeptide. | Cannon, JB., et al. 1996. J Drug Target. 4: 69-78. PMID: 8894966
- Neostriatal neurons of rats can be influenced by cholecystokinin-A receptor agonists. | Davidowa, H., et al. 1997. Neuropeptides. 31: 231-5. PMID: 9243519
Inhibitor of:
RAMP2.Activator of:
CCK.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
A-71623, 1 mg | sc-203487 | 1 mg | $284.00 |