A 61603 HYDROBROMIDE is a potent alpha1A-AR (α-adrenoceptor) agonist, at least 35-fold more potent at α1A-ar than at α1B or α1D sites. Induces dose response increases in spontaneous Ca2+ transients in rat ventricular myocytes in vitro.
Knepper et al (1995) A-61603, a potent a1-adrenergic receptor agonist, selective for the a1A receptor subtype. J.Pharmacol.Exp.Ther. 274 97. Meyer et al (1996) Synthesis and in vitro characterisation of N-[5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulfonamide and its enantiomers: a novel selective a1A receptor agonist. J.Med.Chem. 39 4116. Luo et al (2007) Receptor subtype involved in a1-adrenergic receptor-mediated Ca2+ signaling in cardiomyocytes. Acta.Pharmacol.Sin. 28 968.