A 419259 trihydrochlorideAn apoptosis inducing agent that inhibits c-Src

A 419259 trihydrochloride (CAS 1435934-25-0)

A 419259 trihydrochloride | CAS 1435934-25-0 is rated 5.0 out of 5 by 1.
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Synonym: 7-[trans-4-(4-Methyl-1-piperazinyl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine trihydrochloride; A419259 trihydrochloride
Application: An apoptosis inducing agent that inhibits c-Src
CAS Number: 1435934-25-0
Purity: ≥98%
Molecular Weight: 592.01
Molecular Formula: C29H34N6O•3HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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A 419259 trihydrochloride is an apoptosis inducing agent that inhibits Src family kinases (c-Src). A 419259 also induces apoptosis in CML cell ines and blocks Stat5 and Erk activation.


References

1. Wilson, M.B., et al. 2002. Oncogene. 21: 8075-8088. PMID: 12444544
2. Zhang, Q., et al. 2004. Cancer Res. 64: 6166-6173. PMID: 15342401
3. Pene-Dumitrescu, T., et al. 2008. Oncogene. 27: 7055-7069. PMID: 18794796

Appearance :
Powder or crystalline
Physical State :
Solid
Solubility :
Soluble in water (10 mg/ml), and DMSO (100 mM).
Storage :
Store at 4° C
IC50 :
Src family kinases (SFK): IC50 = 0.1-0.3 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
SMILES :
CN1CCN(CC1)[C@H]2CC[C@@H](CC2)n3c4ncnc(c4c(c3)c5ccc(cc5)Oc6ccccc6)N.Cl.Cl.Cl

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Certificate of Analysis

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A 419259 trihydrochloride  Product Citations

See how others have used A 419259 trihydrochloride. Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 31326613  Wilkinson, AC.|Ryan, DJ.|Kucinski, I.|Wang, W.|Yang, J.|Nestorowa, S.|Diamanti, E.|Tsang, JC.|Wang, J.|Campos, LS.|Yang, F.|Fu, B.|Wilson, N.|Liu, P.|Gottgens, B.| et al. 2019. Exp. Hematol.

PMID: # 29019987  Yang, J.|Ryan, DJ.|Wang, W.|Tsang, JC.|Lan, G.|Masaki, H.|Gao, X.|Antunes, L.|Yu, Y.|Zhu, Z.|Wang, J.|Kolodziejczyk, AA.|Campos, LS.|Wang, C.|Yang, F.|Zhong, Z.|Fu, B.|Eckersley-Maslin, MA.|Woods, M.|Tanaka, Y.|Chen, X.|Wilkinson, AC.|Bussell, J.|White, J.|Ramirez-Solis, R.|Reik, W.|Göttgens, B.|Teichmann, SA.|Tam, PPL.|Nakauchi, H.|Zou, X.|Lu, L.|Liu, P.| et al. 2017. Nature. 550: 393-397.

PMID: # 23895624  Zhang, X. et al. 2014. ACS Chem. Biol. 9: 139-46.

PMID: # 25305536  Zhang, X. et al. 2014. Stem cell research. 13: 379-89.

Citations 1 to 4 of 4 total
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Rated 5 out of 5 by from Zhang Zhang, et al. (PubMed ID 25305536) treated human ES cells with A-419259, an Src-family kinase inhibitor, and found that these cells maintained the domed morphology, pluripotent colonies and continued to express TRA-1-60, even under different culture conditions. -SCBT Publication Review
Date published: 2015-06-29
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