A 350619 hydrochloride is an activator of soluble guanylyl cyclase (sGC). It activates basal sGC and synergistically activates sGC in the presence of NO. It relaxes cavernosum smooth muscle in vitro and induces penile erections in rats in vivo.
Miller et al (2003) A-350619: a novel activator of soluble guanylyl cyclase. Life Sci. 72 1015. Evgenov et al (2006) NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential. Nat.Rev.Drug Discov. 5 755.
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