A-3 Hydrochloride CAS: 78957-85-4
MF: C12H13ClN2O2S HCl
MW: 321.3
A PKA, PKG, Casein Kinase I and II inhibitor.

A-3 Hydrochloride (CAS 78957-85-4)

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Application: A-3 Hydrochloride is a PKA, PKG, Casein Kinase I and II inhibitor
CAS Number: 78957-85-4
Molecular Weight: 321.3
Molecular Formula: C12H13ClN2O2S HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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A-3 Hydrochloride is an inhibitor of PKA (cAMP-dependent protein kinase, Ki=4.3μM) and cGMP-dependent protein kinase, Ki=3.8μM, PKC (protein kinase C, Ki=47μM), casein kinase I and II, and MLCK (myosin light chain kinase) ( Ki=7.4μM).


References

Naphthalenesulfonamides as calmodulin antagonists and protein kinase inhibitors: M. Inagaki, et al.; Mol. Pharmacol. 29, 577 (1986)

Physical State :
Solid
Solubility :
Soluble in water (50 mg/ml), DMSO (50 mg/ml), 100% ethanol, and Dimethyl sulfoxide.
Storage :
Store at -20° C
Melting Point :
173-176° C
Boiling Point :
480° C at 760 mmHg (Predicted)
Refractive Index :
n20D ~1.64 (Predicted)
IC50 :
Plasmodium falciparum: IC50 = 6.31 µM
Ki Data :
PKG: Ki= 3.8 µM; PKA: Ki= 4.3 µM; Casein kinase II: Ki= 5.1 µM; MLCK: Ki= 7.4 µM; PKC: Ki= 47 µM; Casein kinase I : Ki= 80 µM
pK Values :
pKb: 10.98 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :
MFCD00077311
SMILES :
C1=CC2=C(C=CC=C2Cl)C(=C1)S(=O)(=O)NCCN.Cl

Download SDS (MSDS)

Certificate of Analysis

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