9-EthylguanineUsed to study DNA interactions with organometallic complexes

9-Ethylguanine (CAS 879-08-3)

9-Ethylguanine | CAS 879-08-3 is rated 5.0 out of 5 by 1.
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Synonym: 2-Amino-9-ethyl-6-hydroxypurine; 6-Amino-9-ethyl-2-hydroxypurine; 9-EtG
Application: Used to study DNA interactions with organometallic complexes
CAS Number: 879-08-3
Molecular Weight: 179.18
Molecular Formula: C7H9N5O
* Refer to Certificate of Analysis for lot specific data (including water content).
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9-Ethylguanine is a model nucleobase that is used to study DNA interactions with organometallic complexes, especially those designed to target tumors.


References

1. Lancelot, G. and Hélène, C. 1984. J. Biol. Chem. 259(24): 15046-15050. PMID: 6210285

2. Corral, E. et al. 2009. J. Biol. Inorg. Chem. 14(3): 439-448. PMID: 19085018

3. Hanif, M. et al. 2013. Front Chem. 1 : 27. PMID: 24790955

4. Millett, A.J. et al. 2015. Organometallics. 34(11): 2683-2694. PMID: 26146437

Physical State :
Solid
Solubility :
Soluble in water, and 1N NaOH (9.80-10.20 mg/ml).
Storage :
Store at 4° C
Melting Point :
202.16° C (Predicted)
Boiling Point :
~505.0° C at 760 mmHg (Predicted)
Density :
~1.7 g/cm3 (Predicted)
Refractive Index :
n20D 1.80 (Predicted)
pK Values :
pKa: 0.58 (Predicted), pKb: 10.33 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
95189
MDL Number :
MFCD00057031
SMILES :
CCN1C=NC2=C1NC(=NC2=O)N

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Certificate of Analysis

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Hello, How long the shipment takes to Canada?

Asked by: ario
Thank you for your question. For current availability and shipping lead times for this chemical, 9-Ethylguanine: sc-207221, and other reagents, please contact our Canadian Support Department. Please call us toll-free at (800) 457-3801 option 1, e-mail canada@scbt.com, or use the live chat on our website.
Answered by: Technical Support
Date published: 2017-04-10
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Rated 5 out of 5 by from Hanif et al Hanif et al. (PubMed ID 24790955) found that Ru(II)(arene) complexes showed reactivity to the DNA model nucleobase 9-ethylguanine without altering plasmid DNA structure. -SCBT Publication Review
Date published: 2015-04-16
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