9-DeazaguanineActs as a potent inhibitor of purine nucleoside phosphorylase

9-Deazaguanine (CAS 65996-58-9)

9-Deazaguanine | CAS 65996-58-9 is rated 5.0 out of 5 by 1.
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Synonym: 2-Amino-1,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one; NSC 344522
Application: Acts as a potent inhibitor of purine nucleoside phosphorylase
CAS Number: 65996-58-9
Purity: ≥95%
Molecular Weight: 150.14
Molecular Formula: C6H6N4O
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

9-Deazaguanine is a nucleoside analog that acts as a potent inhibitor of PNP (purine nucleoside phosphorylase).


References

Erion, M.D., et al.: J. Med. Chem., 36, 3771 (1993), Seela, F., et al.: Org. Biomol. Chem., 4, 3993 (2006), Hikishima S., et al.: Bioorg. Med. Chem. Lett., 17, 4173 (2007),

Physical State :
Solid
Solubility :
Soluble in DMSO, and methanol(warmed).
Storage :
Store at 4° C
Melting Point :
>300° C
Boiling Point :
452.7° C at 760 mmHg
Density :
~1.9 g/cm3 (Predicted)
Refractive Index :
n20D 1.89 (Predicted)
IC50 :
Enzymatic A chain of ricin (RTA): IC50 = 1.4 mM (ricinus communis)
pK Values :
pKa: 10.85 (Predicted), pKb: 5.36 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
100684
MDL Number :
MFCD09540493
SMILES :
C1=CNC2=C1NC(=NC2=O)N

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Giavas Giavas-Obrovac et al. (Pubmed ID 20102369) found that 9-Deazaguanine showed anti-leukaemic and anti-lymphoma activities via purine nucleoside phosphorylase inhibition. -SCBT Publication Review
Date published: 2015-04-20
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