9-Deazaguanine is a nucleoside analog that acts as a potent inhibitor of PNP (purine nucleoside phosphorylase).
Erion, M.D., et al.: J. Med. Chem., 36, 3771 (1993), Seela, F., et al.: Org. Biomol. Chem., 4, 3993 (2006), Hikishima S., et al.: Bioorg. Med. Chem. Lett., 17, 4173 (2007),
Soluble in DMSO, and methanol(warmed).
Store at 4° C
452.7° C at 760 mmHg
~1.9 g/cm3 (Predicted)
n20D 1.89 (Predicted)
Enzymatic A chain of ricin (RTA): IC50 = 1.4 mM (ricinus communis)
pKa: 10.85 (Predicted), pKb: 5.36 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Certificate of Analysis
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Rated 5 out of
GiavasGiavas-Obrovac et al. (Pubmed ID 20102369) found that 9-Deazaguanine showed anti-leukaemic and anti-lymphoma activities via purine nucleoside phosphorylase inhibition. -SCBT Publication Review
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