9-Deazaguanine (CAS 65996-58-9)

9-deazaguanine, a nucleoside analog, exhibits potent inhibitory activity against PNP (purine nucleoside phosphorylase). As a synthetic intermediate, it plays a significant role in the production of nucleosides, nucleotides, and other biologically active compounds. Being an analogue of guanine, one of the fundamental bases in DNA and RNA, 9-deazaguanine finds utility in the synthesis of antiviral, antineoplastic, and therapeutic agents. Moreover, it offers valuable insights into the structure and function of nucleic acids, making it useful for scientific research. The synthesis method, scientific research applications, mechanism of action, biochemical and physiological effects, advantages and limitations for lab experiments, and potential future directions of 9-deazaguanine have been extensively investigated. In research applications, it has been employed to study nucleic acid structure and function, develop antiviral and antineoplastic agents, explore nucleic acid-protein interactions, and investigate the impact of mutations on nucleic acid structure and function. Although the exact mechanism of action of 9-deazaguanine remains incompletely understood, it is believed to act as a competitive inhibitor of guanine in the formation of nucleic acid structures. Additionally, it is thought to interfere with guanine binding to proteins and other molecules. The biochemical and physiological effects of 9-deazaguanine are still under investigation, but it is postulated to hinder nucleic acid structure formation and disrupt guanine-protein binding. Furthermore, it may impede DNA and RNA replication. In summary, 9-deazaguanine holds significant promise in scientific research, particularly in the realms of nucleic acid studies, drug development, and understanding the intricate relationships within nucleic acid systems. Further exploration is required to uncover its full potential and shed light on its biochemical and physiological effects.