9,12-Octadecadiynoic Acid is an inhibitor of both Cox and LO (lipoxygenase). 9,12-Octadecadiynoic Acid inhibits ram seminal vesicle Cox with a Ki of 0.6 μM. It is a more effective inhibitor of Cox-1 than of 15-LO, inhibiting 95% and 68%, respectively, of these enzymatic activities when used at a concentration of 48 μM.
1 Vanderhoek, J.Y., Lands, W.E.M. Acetylenic inhibitors of sheep vesicular gland oxygenase. Biochim Biophys Acta 296 374-381 (1973). 2 Downing, D.T., Barve, J.A., Gunstone, F.D., et al. Structural requirements of acetylenic fatty acids for inhibition of soybean lipoxygenase and prostaglandin synthase. Biochim Biophys Acta 280 343-347 (1972).
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