9,12-Octadecadiynoic AcidCAS: 2012-14-8
MF: C18H28O2
MW: 276.4
An inhibitor of Cox and LO.

9,12-Octadecadiynoic Acid (CAS 2012-14-8)

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Synonym: Ro 3-1314
Application: An inhibitor of Cox and LO
CAS Number: 2012-14-8
Molecular Weight: 276.4
Molecular Formula: C18H28O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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9,12-Octadecadiynoic Acid is an inhibitor of both Cox and LO (lipoxygenase). 9,12-Octadecadiynoic Acid inhibits ram seminal vesicle Cox with a Ki of 0.6 μM. It is a more effective inhibitor of Cox-1 than of 15-LO, inhibiting 95% and 68%, respectively, of these enzymatic activities when used at a concentration of 48 μM.


References

1 Vanderhoek, J.Y., Lands, W.E.M. Acetylenic inhibitors of sheep vesicular gland oxygenase. Biochim Biophys Acta 296 374-381 (1973). 2 Downing, D.T., Barve, J.A., Gunstone, F.D., et al. Structural requirements of acetylenic fatty acids for inhibition of soybean lipoxygenase and prostaglandin synthase. Biochim Biophys Acta 280 343-347 (1972).

Physical State :
Solid
Storage :
Store at -20° C
Melting Point :
45.00-46.00° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
1931
SMILES :
CCCCCC#CCC#CCCCCCCCC(=O)O

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Certificate of Analysis

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