8-Methoxymethyl-IBMXA Cam-PDE selective inhibitor

8-Methoxymethyl-IBMX (CAS 78033-08-6)

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Synonym: 8-Methoxymethyl-3-isobutyl-1-methylxanthine
Application: A Cam-PDE selective inhibitor
CAS Number: 78033-08-6
Purity: 98%
Molecular Weight: 266.3
Molecular Formula: C12H18N4O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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8-Methoxymethyl-IBMX has been reported to be a selective and potent inhibitor of calmodulin-stimulated PDE (phosphodiesterase). 8-Methoxymethyl-IBMX causes an increase in cGMP but not cAMP, prolonging signal transduction for cGMP-dependent pathways. Experiments performed on catheterized rabbits with acute pulmonary hypertension show that the compound may cause a decrease in pulmonary artery pressure by causing vasodilation.


References

1. Ahn, H.S., et al. 1989. Biochem. Pharmacol. 38: 3331-3339. PMID: 2554921
2. Yu, J., et al. 1997. Cell. Signal. 9: 519-529. PMID: 9419816
3. Schermuly, R.T., et al. 2005. Respir. Res. 6: 76. PMID: 16033645
4. Marte, A., et al. 2008. J. Neurosci. Res. 86: 3338-3347. PMID: 18655195

Physical State :
Solid
Solubility :
Soluble in ethanol (10 mg/ml), and DMSO (5 mg/ml).
Storage :
Store at -20° C
Melting Point :
194-200° C
Boiling Point :
~476.4° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.55 (Predicted)
IC50 :
PDE 1: IC50 = 4 µM; Phosphodiesterase 1B: IC50 = 8 µM (bovine); Phosphodiesterase 5A: IC50 = 10 µM (bovine); Phosphodiesterase 3B: IC50 = 240 µM (bovine); calmodulin-sensitive cyclic GMP phosphodiesterase: IC50 = 5.2 µM; Phosphodiesterase 1A: IC50 = 8 µM (bovine)
pK Values :
pKa: 8.18, pKb: 1.02
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
155806
MDL Number :
MFCD00211081
SMILES :
CC(C)CN1C2=C(C(=O)N(C1=O)C)NC(=N2)COC

Download SDS (MSDS)

Certificate of Analysis

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