8-HydroxyguanosineA product of oxidative damage to RNA

8-Hydroxyguanosine (CAS 3868-31-3)

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Synonym: 8-Oxoguanosine
Application: A product of oxidative damage to RNA
CAS Number: 3868-31-3
Purity: ≥98%
Molecular Weight: 299.24
Molecular Formula: C10H13N5O6
* Refer to Certificate of Analysis for lot specific data (including water content).
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8-Hydroxyguanosine is the oxidized form of the nucleoside guanosine. Produced by the free radical oxidation of RNA molecules, with subsequent degradation and cleavage of the nucleic acid.


References

1. Mo, J Y., et al., 1992. Hydrolytic elimination of a mutagenic nucleotide, 8-oxodGTP, by human 18-kilodalton protein: sanitization of nucleotide pool. Proceedings of the National Academy of Sciences of the United States of America. 89(22): 11021-5. PMID: 1332067
2. Lin, T S., et al., 1985. 8-Substituted guanosine and 2'-deoxyguanosine derivatives as potential inducers of the differentiation of Friend erythroleukemia cells. Journal of medicinal chemistry. 28(9): 1194-8. PMID: 3861870
3. Kuo, M L., et al., 1998. Involvement of oxidative stress in motorcycle exhaust particle-induced DNA damage and inhibition of intercellular communication. Mutation research. 413(2): 143-50. PMID: 9639694
4. Lodovici, M., et al., 2000. Levels of 8-hydroxydeoxyguanosine as a marker of DNA damage in human leukocytes. Free radical biology & medicine. 28(1): 13-7. PMID: 10656286

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in ethanol, DMF.Soluble in conc. NaOH. Once solubilized it can be further diluted and neutralized.
Storage :
Store at -20° C
Melting Point :
232-235° C
Boiling Point :
666.93° C (Predicted)
Density :
2.44 g/cm3
Refractive Index :
n20D 2.01
pK Values :
pKa: 8.46, pKb: 2.79
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
UO8175725
PubChem CID :
259811
MDL Number :
MFCD00216136
SMILES :
C(C1C(C(C(O1)N2C3=C(C(=O)N=C(N3)N)NC2=O)O)O)O

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Certificate of Analysis

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8-Hydroxyguanosine  Product Citations

See how others have used 8-Hydroxyguanosine. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 28341989  2017. Anal Bioanal Chem. 409: 3611-3621.

Citations 1 to 1 of 1 total
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